Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography

Deepa Kasaragod; Kin Man Au; Zenghai Lu; David Childs; Steven P. Armes; Stephen J. Matcher

doi:10.1117/12.2004024

Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography

Deepa Kasaragod, Kin Man Au, Zenghai Lu, David Childs, Steven P. Armes, Stephen J. Matcher

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

We report on a photothermal modulation detection scheme developed using a swept source-based optical coherence tomography (OCT) system centred at 1300nm. Photothermal detection is an improved technique for studying the contrast properties of exogenous contrast agents such as highly absorbing polypyrrole (PPy) nanoparticles used for OCT imaging. The swept source based OCT system has a wavelength sweep rate of 10 kHz which is used for the phase modulation detection of various concentrations of PPy nanoparticles. PPy nanoparticles have been recently reported to be a promising candidate for OCT imaging owing to their strong NIR absorption from 700-1300nm. Phase-sensitive detection of the photothermal modulation signal is achieved using a pumped 975 nm laser beam at 80Hz and 160Hz for varying concentrations of PPy nanoparticles dispersed in 2% Intralipid phantom. A phase-sensitive detection system is realised by carrying out the phase calibration using the back reflections obtained from the coverslip used with the sample. This study provides quantitative support for the use of PPy nanoparticles as a potential biocompatible contrast agent in OCT imaging.

Original language	English
Title of host publication	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Editors	Samuel Achilefu, Ramesh Raghavachari
Publisher	SPIE
Number of pages	7
Volume	8596
ISBN (Print)	9780819493651
DOIs	https://doi.org/10.1117/12.2004024
Publication status	Published - 21 Feb 2013
Externally published	Yes
Event	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, United States Duration: 2 Feb 2013 → 7 Feb 2013 Conference number: 5

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8596
ISSN (Print)	1605-7422

Conference

Conference	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Country/Territory	United States
City	San Francisco
Period	2/02/13 → 7/02/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Kasaragod, D., Au, K. M., Lu, Z., Childs, D., Armes, S. P., & Matcher, S. J. (2013). Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. In S. Achilefu, & R. Raghavachari (Eds.), Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V (Vol. 8596). [85960R] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8596). SPIE. https://doi.org/10.1117/12.2004024

Kasaragod, Deepa ; Au, Kin Man ; Lu, Zenghai et al. / Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V. editor / Samuel Achilefu ; Ramesh Raghavachari. Vol. 8596 SPIE, 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography",

abstract = "We report on a photothermal modulation detection scheme developed using a swept source-based optical coherence tomography (OCT) system centred at 1300nm. Photothermal detection is an improved technique for studying the contrast properties of exogenous contrast agents such as highly absorbing polypyrrole (PPy) nanoparticles used for OCT imaging. The swept source based OCT system has a wavelength sweep rate of 10 kHz which is used for the phase modulation detection of various concentrations of PPy nanoparticles. PPy nanoparticles have been recently reported to be a promising candidate for OCT imaging owing to their strong NIR absorption from 700-1300nm. Phase-sensitive detection of the photothermal modulation signal is achieved using a pumped 975 nm laser beam at 80Hz and 160Hz for varying concentrations of PPy nanoparticles dispersed in 2% Intralipid phantom. A phase-sensitive detection system is realised by carrying out the phase calibration using the back reflections obtained from the coverslip used with the sample. This study provides quantitative support for the use of PPy nanoparticles as a potential biocompatible contrast agent in OCT imaging.",

keywords = "OCT contrast agent, Photothermal OCT, polypyrrole nanoparticles, Optical coherence tomography, Nanoparticles, Modulation, Phase shift keying, Calibration, Near infrared, Solids, Absorption, Particles, Signal detection",

author = "Deepa Kasaragod and Au, {Kin Man} and Zenghai Lu and David Childs and Armes, {Steven P.} and Matcher, {Stephen J.}",

year = "2013",

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doi = "10.1117/12.2004024",

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Kasaragod, D, Au, KM, Lu, Z, Childs, D, Armes, SP & Matcher, SJ 2013, Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. in S Achilefu & R Raghavachari (eds), Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V. vol. 8596, 85960R, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8596, SPIE, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, San Francisco, California, United States, 2/02/13. https://doi.org/10.1117/12.2004024

Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. / Kasaragod, Deepa; Au, Kin Man; Lu, Zenghai et al.

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V. ed. / Samuel Achilefu; Ramesh Raghavachari. Vol. 8596 SPIE, 2013. 85960R (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8596).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography

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AU - Au, Kin Man

AU - Lu, Zenghai

AU - Childs, David

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AU - Matcher, Stephen J.

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N2 - We report on a photothermal modulation detection scheme developed using a swept source-based optical coherence tomography (OCT) system centred at 1300nm. Photothermal detection is an improved technique for studying the contrast properties of exogenous contrast agents such as highly absorbing polypyrrole (PPy) nanoparticles used for OCT imaging. The swept source based OCT system has a wavelength sweep rate of 10 kHz which is used for the phase modulation detection of various concentrations of PPy nanoparticles. PPy nanoparticles have been recently reported to be a promising candidate for OCT imaging owing to their strong NIR absorption from 700-1300nm. Phase-sensitive detection of the photothermal modulation signal is achieved using a pumped 975 nm laser beam at 80Hz and 160Hz for varying concentrations of PPy nanoparticles dispersed in 2% Intralipid phantom. A phase-sensitive detection system is realised by carrying out the phase calibration using the back reflections obtained from the coverslip used with the sample. This study provides quantitative support for the use of PPy nanoparticles as a potential biocompatible contrast agent in OCT imaging.

AB - We report on a photothermal modulation detection scheme developed using a swept source-based optical coherence tomography (OCT) system centred at 1300nm. Photothermal detection is an improved technique for studying the contrast properties of exogenous contrast agents such as highly absorbing polypyrrole (PPy) nanoparticles used for OCT imaging. The swept source based OCT system has a wavelength sweep rate of 10 kHz which is used for the phase modulation detection of various concentrations of PPy nanoparticles. PPy nanoparticles have been recently reported to be a promising candidate for OCT imaging owing to their strong NIR absorption from 700-1300nm. Phase-sensitive detection of the photothermal modulation signal is achieved using a pumped 975 nm laser beam at 80Hz and 160Hz for varying concentrations of PPy nanoparticles dispersed in 2% Intralipid phantom. A phase-sensitive detection system is realised by carrying out the phase calibration using the back reflections obtained from the coverslip used with the sample. This study provides quantitative support for the use of PPy nanoparticles as a potential biocompatible contrast agent in OCT imaging.

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BT - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V

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PB - SPIE

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Y2 - 2 February 2013 through 7 February 2013

ER -

Kasaragod D, Au KM, Lu Z, Childs D, Armes SP, Matcher SJ. Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. In Achilefu S, Raghavachari R, editors, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V. Vol. 8596. SPIE. 2013. 85960R. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2004024

Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography

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