Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa

Fulvio Cruciani, Roberta La Fratta, Piero Santolamazza, Daniele Sellitto, Roberto Pascone, Pedro Moral, Elizabeth Watson, Valentina Guida, Eliane Beraud Colomb, Boriana Zaharova, João Lavinha, Giuseppe Vona, Rashid Aman, Francesco Calì, Nejat Akar, Martin Richards, Antonio Torroni, Andrea Novelletto, Rosaria Scozzari

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3,401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25,000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a dose haplogroup-ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny.

LanguageEnglish
Pages1014-1022
Number of pages9
JournalAmerican Journal of Human Genetics
Volume74
Issue number5
Early online date24 Mar 2004
DOIs
Publication statusPublished - May 2004
Externally publishedYes

Fingerprint

Chromosomes, Human, 16-18
Y Chromosome
Phylogeny
Phylogeography
Western Africa
Ethiopia
Middle East
Gene Flow
Population Genetics
Genetic Markers
Ethnic Groups
Population

Cite this

Cruciani, F., La Fratta, R., Santolamazza, P., Sellitto, D., Pascone, R., Moral, P., ... Scozzari, R. (2004). Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa. American Journal of Human Genetics, 74(5), 1014-1022. https://doi.org/10.1086/386294
Cruciani, Fulvio ; La Fratta, Roberta ; Santolamazza, Piero ; Sellitto, Daniele ; Pascone, Roberto ; Moral, Pedro ; Watson, Elizabeth ; Guida, Valentina ; Colomb, Eliane Beraud ; Zaharova, Boriana ; Lavinha, João ; Vona, Giuseppe ; Aman, Rashid ; Calì, Francesco ; Akar, Nejat ; Richards, Martin ; Torroni, Antonio ; Novelletto, Andrea ; Scozzari, Rosaria. / Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa. In: American Journal of Human Genetics. 2004 ; Vol. 74, No. 5. pp. 1014-1022.
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abstract = "We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3,401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25,000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a dose haplogroup-ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny.",
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Cruciani, F, La Fratta, R, Santolamazza, P, Sellitto, D, Pascone, R, Moral, P, Watson, E, Guida, V, Colomb, EB, Zaharova, B, Lavinha, J, Vona, G, Aman, R, Calì, F, Akar, N, Richards, M, Torroni, A, Novelletto, A & Scozzari, R 2004, 'Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa', American Journal of Human Genetics, vol. 74, no. 5, pp. 1014-1022. https://doi.org/10.1086/386294

Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa. / Cruciani, Fulvio; La Fratta, Roberta; Santolamazza, Piero; Sellitto, Daniele; Pascone, Roberto; Moral, Pedro; Watson, Elizabeth; Guida, Valentina; Colomb, Eliane Beraud; Zaharova, Boriana; Lavinha, João; Vona, Giuseppe; Aman, Rashid; Calì, Francesco; Akar, Nejat; Richards, Martin; Torroni, Antonio; Novelletto, Andrea; Scozzari, Rosaria.

In: American Journal of Human Genetics, Vol. 74, No. 5, 05.2004, p. 1014-1022.

Research output: Contribution to journalArticle

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T1 - Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out of Africa

AU - Cruciani, Fulvio

AU - La Fratta, Roberta

AU - Santolamazza, Piero

AU - Sellitto, Daniele

AU - Pascone, Roberto

AU - Moral, Pedro

AU - Watson, Elizabeth

AU - Guida, Valentina

AU - Colomb, Eliane Beraud

AU - Zaharova, Boriana

AU - Lavinha, João

AU - Vona, Giuseppe

AU - Aman, Rashid

AU - Calì, Francesco

AU - Akar, Nejat

AU - Richards, Martin

AU - Torroni, Antonio

AU - Novelletto, Andrea

AU - Scozzari, Rosaria

PY - 2004/5

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N2 - We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3,401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25,000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a dose haplogroup-ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny.

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