Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction

Chia Siang Kow; Dinesh Sangarran Ramachandram; Syed Shahzad Hasan

doi:10.1111/coa.13892

Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan

Research output: Contribution to journal › Letter › peer-review

Abstract

We read with interest the retrospective cohort study by Taziki Balajelini et al. [1], which investigated the relationship between viral load and the incidences of olfactory dysfunction (OD) and gustatory dysfunction (GD) in patients with COVID-19. In the study, the authors observed a significantly higher (p=0.001) mean cycle threshold (Ct) value of RT-PCR test for SARS-CoV-2 between patients with (28.13±4.55) and without OD (26.91±4.49). The Ct values of the RT-PCR test for SARS-CoV-2 correlate inversely with the viral load, where low Ct values indicate high viral loads and vice versa; therefore, the findings of the study suggest a lower viral load in patients with OD.

Original language	English
Pages (from-to)	397-398
Number of pages	2
Journal	Clinical Otolaryngology
Volume	47
Issue number	2
Early online date	29 Nov 2021
DOIs	https://doi.org/10.1111/coa.13892
Publication status	Published - 1 Mar 2022

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title = "Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction",

abstract = "We read with interest the retrospective cohort study by Taziki Balajelini et al. [1], which investigated the relationship between viral load and the incidences of olfactory dysfunction (OD) and gustatory dysfunction (GD) in patients with COVID-19. In the study, the authors observed a significantly higher (p=0.001) mean cycle threshold (Ct) value of RT-PCR test for SARS-CoV-2 between patients with (28.13±4.55) and without OD (26.91±4.49). The Ct values of the RT-PCR test for SARS-CoV-2 correlate inversely with the viral load, where low Ct values indicate high viral loads and vice versa; therefore, the findings of the study suggest a lower viral load in patients with OD.",

keywords = "COVID-19, Viral load, Olfactory dysfunction (OD), Gustatory dysfunction (GD), Coronavirus, Smell loss, Taste loss, smell loss, taste loss, coronavirus, gustatory, olfactory",

author = "Kow, {Chia Siang} and Ramachandram, {Dinesh Sangarran} and Hasan, {Syed Shahzad}",

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T1 - Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction

AU - Kow, Chia Siang

AU - Ramachandram, Dinesh Sangarran

AU - Hasan, Syed Shahzad

PY - 2022/3/1

Y1 - 2022/3/1

N2 - We read with interest the retrospective cohort study by Taziki Balajelini et al. [1], which investigated the relationship between viral load and the incidences of olfactory dysfunction (OD) and gustatory dysfunction (GD) in patients with COVID-19. In the study, the authors observed a significantly higher (p=0.001) mean cycle threshold (Ct) value of RT-PCR test for SARS-CoV-2 between patients with (28.13±4.55) and without OD (26.91±4.49). The Ct values of the RT-PCR test for SARS-CoV-2 correlate inversely with the viral load, where low Ct values indicate high viral loads and vice versa; therefore, the findings of the study suggest a lower viral load in patients with OD.

AB - We read with interest the retrospective cohort study by Taziki Balajelini et al. [1], which investigated the relationship between viral load and the incidences of olfactory dysfunction (OD) and gustatory dysfunction (GD) in patients with COVID-19. In the study, the authors observed a significantly higher (p=0.001) mean cycle threshold (Ct) value of RT-PCR test for SARS-CoV-2 between patients with (28.13±4.55) and without OD (26.91±4.49). The Ct values of the RT-PCR test for SARS-CoV-2 correlate inversely with the viral load, where low Ct values indicate high viral loads and vice versa; therefore, the findings of the study suggest a lower viral load in patients with OD.

KW - COVID-19

KW - Viral load

KW - Olfactory dysfunction (OD)

KW - Gustatory dysfunction (GD)

KW - Coronavirus

KW - Smell loss

KW - Taste loss

KW - smell loss

KW - taste loss

KW - coronavirus

KW - gustatory

KW - olfactory

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DO - 10.1111/coa.13892

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JF - Clinical Otolaryngology and Allied Sciences

SN - 1749-4478

IS - 2

ER -

Physiological plausibility of lower viral load in patients with COVID-19 and olfactory/gustatory dysfunction

Abstract

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