Physiology of the Gastrointestinal System

J-M. Sauer, Hamid Merchant

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Gastrointestinal (GI) physiology describes the normal functions of the digestive tract, particularly that of its hollow organs. Within the oropharynx, oesophagus, stomach, small bowel, colon, and rectum, nutrient solids and fluids are ingested, propelled, mixed, digested, and absorbed while non-absorbable materials are stored and excreted. Critical to the digestive process are the exocrine secretions of the pancreas, liver, and gastrointestinal mucosae. These secretions break and dissolve the large, complex, ingested molecules of food into smaller compounds, which are then ready for absorption into the intestinal epithelium and its circulation. The gastrointestinal wall embedding transporters and mucosal enzymes critically controls the absorption of nutrition and exogenous substances, such as drugs, across GI mucosa. The chapter gives an overview of the three major physiological functions of the gastrointestinal system, i.e., are motility, secretion, and digestion/absorption, influencing the fate of nutrition and pharmaceuticals administered into the GI tract.
LanguageEnglish
Title of host publicationComprehensive Toxicology
EditorsCharlene McQueen
PublisherElsevier
Chapter3.03
Pages16-44
Number of pages29
Edition3rd
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
Publication statusPublished - 2018

Fingerprint

Physiology
Nutrition
Gastrointestinal Agents
Liver
Nutrients
Molecules
Fluids
Enzymes
Pharmaceutical Preparations
Mucous Membrane

Cite this

Sauer, J-M., & Merchant, H. (2018). Physiology of the Gastrointestinal System. In C. McQueen (Ed.), Comprehensive Toxicology (3rd ed., pp. 16-44). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.99195-5
Sauer, J-M. ; Merchant, Hamid. / Physiology of the Gastrointestinal System. Comprehensive Toxicology. editor / Charlene McQueen. 3rd. ed. Elsevier, 2018. pp. 16-44
@inbook{7e1960ee92b24b1a87373c87bb4b9979,
title = "Physiology of the Gastrointestinal System",
abstract = "Gastrointestinal (GI) physiology describes the normal functions of the digestive tract, particularly that of its hollow organs. Within the oropharynx, oesophagus, stomach, small bowel, colon, and rectum, nutrient solids and fluids are ingested, propelled, mixed, digested, and absorbed while non-absorbable materials are stored and excreted. Critical to the digestive process are the exocrine secretions of the pancreas, liver, and gastrointestinal mucosae. These secretions break and dissolve the large, complex, ingested molecules of food into smaller compounds, which are then ready for absorption into the intestinal epithelium and its circulation. The gastrointestinal wall embedding transporters and mucosal enzymes critically controls the absorption of nutrition and exogenous substances, such as drugs, across GI mucosa. The chapter gives an overview of the three major physiological functions of the gastrointestinal system, i.e., are motility, secretion, and digestion/absorption, influencing the fate of nutrition and pharmaceuticals administered into the GI tract.",
keywords = "Absoprtion, Colon, Colonic drug delivery, Gastric emptying, Gastrointestinal physiology, Gastrointestinal secretion, Gastrointestinal tract, Migrating motor complex, Motility, Oral drug delivery, Rectal drug delivery, Small intestine, Transit, Digestion, Absorption",
author = "J-M. Sauer and Hamid Merchant",
year = "2018",
doi = "10.1016/B978-0-12-801238-3.99195-5",
language = "English",
isbn = "9780081006016",
pages = "16--44",
editor = "Charlene McQueen",
booktitle = "Comprehensive Toxicology",
publisher = "Elsevier",
address = "Netherlands",
edition = "3rd",

}

Sauer, J-M & Merchant, H 2018, Physiology of the Gastrointestinal System. in C McQueen (ed.), Comprehensive Toxicology. 3rd edn, Elsevier, pp. 16-44. https://doi.org/10.1016/B978-0-12-801238-3.99195-5

Physiology of the Gastrointestinal System. / Sauer, J-M.; Merchant, Hamid.

Comprehensive Toxicology. ed. / Charlene McQueen. 3rd. ed. Elsevier, 2018. p. 16-44.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Physiology of the Gastrointestinal System

AU - Sauer, J-M.

AU - Merchant, Hamid

PY - 2018

Y1 - 2018

N2 - Gastrointestinal (GI) physiology describes the normal functions of the digestive tract, particularly that of its hollow organs. Within the oropharynx, oesophagus, stomach, small bowel, colon, and rectum, nutrient solids and fluids are ingested, propelled, mixed, digested, and absorbed while non-absorbable materials are stored and excreted. Critical to the digestive process are the exocrine secretions of the pancreas, liver, and gastrointestinal mucosae. These secretions break and dissolve the large, complex, ingested molecules of food into smaller compounds, which are then ready for absorption into the intestinal epithelium and its circulation. The gastrointestinal wall embedding transporters and mucosal enzymes critically controls the absorption of nutrition and exogenous substances, such as drugs, across GI mucosa. The chapter gives an overview of the three major physiological functions of the gastrointestinal system, i.e., are motility, secretion, and digestion/absorption, influencing the fate of nutrition and pharmaceuticals administered into the GI tract.

AB - Gastrointestinal (GI) physiology describes the normal functions of the digestive tract, particularly that of its hollow organs. Within the oropharynx, oesophagus, stomach, small bowel, colon, and rectum, nutrient solids and fluids are ingested, propelled, mixed, digested, and absorbed while non-absorbable materials are stored and excreted. Critical to the digestive process are the exocrine secretions of the pancreas, liver, and gastrointestinal mucosae. These secretions break and dissolve the large, complex, ingested molecules of food into smaller compounds, which are then ready for absorption into the intestinal epithelium and its circulation. The gastrointestinal wall embedding transporters and mucosal enzymes critically controls the absorption of nutrition and exogenous substances, such as drugs, across GI mucosa. The chapter gives an overview of the three major physiological functions of the gastrointestinal system, i.e., are motility, secretion, and digestion/absorption, influencing the fate of nutrition and pharmaceuticals administered into the GI tract.

KW - Absoprtion

KW - Colon

KW - Colonic drug delivery

KW - Gastric emptying

KW - Gastrointestinal physiology

KW - Gastrointestinal secretion

KW - Gastrointestinal tract

KW - Migrating motor complex

KW - Motility

KW - Oral drug delivery

KW - Rectal drug delivery

KW - Small intestine

KW - Transit

KW - Digestion

KW - Absorption

UR - http://www.sciencedirect.com/science?_ob=RefWorkIndexURL&_idxType=GI&_cid=318427&md5=c5f4be76ea0c9d9af3e33999b1c70525

UR - http://www.scopus.com/inward/record.url?scp=85043324942&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-801238-3.99195-5

DO - 10.1016/B978-0-12-801238-3.99195-5

M3 - Chapter

SN - 9780081006016

SP - 16

EP - 44

BT - Comprehensive Toxicology

A2 - McQueen, Charlene

PB - Elsevier

ER -

Sauer J-M, Merchant H. Physiology of the Gastrointestinal System. In McQueen C, editor, Comprehensive Toxicology. 3rd ed. Elsevier. 2018. p. 16-44 https://doi.org/10.1016/B978-0-12-801238-3.99195-5