Piperolein B, Isopiperolein B and Piperamide C9:1(8E): Total Synthesis and Cytotoxicities

Christopher Dunnill; Arantxa Rodríguez; Nikolaos T. Georgopoulos; Wesley J. Moran; Francis Kayamba; David J. Hamnett

doi:10.1039/c3ra42060d

Piperolein B, Isopiperolein B and Piperamide C9:1(8E): Total Synthesis and Cytotoxicities

Christopher Dunnill, Arantxa Rodríguez, Nikolaos T. Georgopoulos, Wesley J. Moran, Francis Kayamba, David J. Hamnett

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

Original language	English
Pages (from-to)	16681-16685
Number of pages	5
Journal	RSC Advances
Volume	3
Issue number	37
DOIs	https://doi.org/10.1039/c3ra42060d
Publication status	Published - 15 Jul 2013

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abstract = "Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.",

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T1 - Piperolein B, Isopiperolein B and Piperamide C9:1(8E)

T2 - Total Synthesis and Cytotoxicities

AU - Dunnill, Christopher

AU - Rodríguez, Arantxa

AU - Georgopoulos, Nikolaos T.

AU - Moran, Wesley J.

AU - Kayamba, Francis

AU - Hamnett, David J.

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

AB - Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

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ER -

Piperolein B, Isopiperolein B and Piperamide C9:1(8E): Total Synthesis and Cytotoxicities

Abstract

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