Piperolein B, Isopiperolein B and Piperamide C9:1(8E): Total Synthesis and Cytotoxicities

Christopher Dunnill, Arantxa Rodríguez, Nikolaos T. Georgopoulos, Wesley J. Moran, Francis Kayamba, David J. Hamnett

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

Original languageEnglish
Pages (from-to)16681-16685
Number of pages5
JournalRSC Advances
Volume3
Issue number37
DOIs
Publication statusPublished - 15 Jul 2013

Fingerprint

Cytotoxicity
Cells
Tissue

Cite this

@article{84830f397e264f10a698a38612cfd3de,
title = "Piperolein B, Isopiperolein B and Piperamide C9:1(8E): Total Synthesis and Cytotoxicities",
abstract = "Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.",
author = "Christopher Dunnill and Arantxa Rodr{\'i}guez and Georgopoulos, {Nikolaos T.} and Moran, {Wesley J.} and Francis Kayamba and Hamnett, {David J.}",
year = "2013",
month = "7",
day = "15",
doi = "10.1039/c3ra42060d",
language = "English",
volume = "3",
pages = "16681--16685",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "37",

}

Piperolein B, Isopiperolein B and Piperamide C9:1(8E) : Total Synthesis and Cytotoxicities. / Dunnill, Christopher; Rodríguez, Arantxa; Georgopoulos, Nikolaos T.; Moran, Wesley J.; Kayamba, Francis; Hamnett, David J.

In: RSC Advances, Vol. 3, No. 37, 15.07.2013, p. 16681-16685.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Piperolein B, Isopiperolein B and Piperamide C9:1(8E)

T2 - Total Synthesis and Cytotoxicities

AU - Dunnill, Christopher

AU - Rodríguez, Arantxa

AU - Georgopoulos, Nikolaos T.

AU - Moran, Wesley J.

AU - Kayamba, Francis

AU - Hamnett, David J.

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

AB - Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

UR - http://www.scopus.com/inward/record.url?scp=84883392788&partnerID=8YFLogxK

U2 - 10.1039/c3ra42060d

DO - 10.1039/c3ra42060d

M3 - Article

VL - 3

SP - 16681

EP - 16685

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 37

ER -