Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher
degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed
the successful fabrication of extended release matrices.
FingerprintDive into the research topics of 'Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies'. Together they form a unique fingerprint.
- Department of Pharmacy - Senior Research Fellow
- School of Applied Sciences
- Pharmaceutics and Drug Delivery Centre - Member
- Biorefinery Engineering and Bioprocessing Research Centre - Member
- Technical Textiles Research Centre - Associate Member
- Pharmaceutical Policy and Practice Research Centre - Associate Member
- Biopolymer Research Centre - Associate Member