Plasticiser-Free 3D Printed Hydrophilic Matrices

Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

Zara Khizer, Muhammad R. Akram, Rai M. Sarfraz, Jorabar Nirwan, Samia Farhaj, Maria Yousaf, Tariq Hussain, Shan Lou, Peter Timmins, Barbara Conway, Muhammad Usman Ghori

Research output: Contribution to journalArticle

Abstract

Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated.
Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher
degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed
the successful fabrication of extended release matrices.
Original languageEnglish
Article number1095
Number of pages18
JournalPolymers
Volume11
Issue number7
DOIs
Publication statusPublished - 28 Jun 2019

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Plasticizers
Pharmacokinetics
Swelling
Erosion
Textures
Viscosity
Tablets
Dissolution
Pharmaceutical Preparations
Fabrication
Extrusion
Printing
Cellulose
Porosity
Glipizide
Polymers

Cite this

Khizer, Zara ; Muhammad R. Akram ; Rai M. Sarfraz ; Nirwan, Jorabar ; Farhaj, Samia ; Yousaf, Maria ; Tariq Hussain ; Lou, Shan ; Timmins, Peter ; Conway, Barbara ; Ghori, Muhammad Usman . / Plasticiser-Free 3D Printed Hydrophilic Matrices : Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies. In: Polymers. 2019 ; Vol. 11, No. 7.
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abstract = "Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated.Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105{\%}), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higherdegree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealedthe successful fabrication of extended release matrices.",
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Plasticiser-Free 3D Printed Hydrophilic Matrices : Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies. / Khizer, Zara; Muhammad R. Akram; Rai M. Sarfraz; Nirwan, Jorabar; Farhaj, Samia; Yousaf, Maria; Tariq Hussain ; Lou, Shan; Timmins, Peter; Conway, Barbara; Ghori, Muhammad Usman .

In: Polymers, Vol. 11, No. 7, 1095, 28.06.2019.

Research output: Contribution to journalArticle

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T1 - Plasticiser-Free 3D Printed Hydrophilic Matrices

T2 - Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

AU - Khizer, Zara

AU - Muhammad R. Akram

AU - Rai M. Sarfraz

AU - Nirwan, Jorabar

AU - Farhaj, Samia

AU - Yousaf, Maria

AU - Tariq Hussain

AU - Lou, Shan

AU - Timmins, Peter

AU - Conway, Barbara

AU - Ghori, Muhammad Usman

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated.Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higherdegree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealedthe successful fabrication of extended release matrices.

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KW - 3D surface texture

KW - Drug release

KW - Erosion

KW - Hot melt extrusion

KW - Hydroxypropyl methyl cellulose (HPMC)

KW - Pharmacokinetics

KW - Swelling

KW - Young's modulus

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M3 - Article

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