Poly(dimethylsiloxane): A Sustainable Human Skin Alternative for Transdermal Drug Delivery Prediction

Sani Sabo, Laura J. Waters

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Despite the advantages of transdermal drug delivery (TDD), which makes it a fast-growing area of research in pharmaceutics, numerous challenges affect their development, which limits exploring the full potential of this alternate drug delivery route. In trying to address one of these problems, it is strongly believed that the need for a sustainable skin alternative is paramount. Efforts made in an attempt to provide a sustainable alternative to employing skin in pharmaceutical analysis, by better utilising a polymer membrane, namely poly(dimethylsiloxane), also known as PDMS are discussed. Several combined properties of this polymer, which includes its relative stability in comparison with human skin, make it a good candidate for the replacement of skin. Modifications undertaken to this polymer membrane (to create an enhanced skin mimic for permeation analysis) are discussed and reviewed in this paper, including the improved ability to predict permeability for both hydrophobic and hydrophilic drugs. Optimisations related to studying TDD including limitations encountered are also documented and reviewed. It is hoped that such developments in this field will ultimately lead to researchers replacing skin with optimised polymer-based alternatives to predict transdermal drug delivery.

Original languageEnglish
Pages (from-to)1018-1024
Number of pages7
JournalJournal of Pharmaceutical Sciences
Issue number3
Early online date1 Dec 2020
Publication statusPublished - 1 Mar 2021


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