Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. Silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.
Mohamed, H. A., Khuphe, M., Boardman, S. J., Shepherd, S., Phillips, R., Harvey, P. D., & Willans, C. E. (2018). Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes. RSC Advances, 8(19), 10474-10477. https://doi.org/10.1039/C8RA00450A