Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

H. A. Mohamed; M. Khuphe; S. J. Boardman; Samantha Shepherd; Roger Phillips; P.D. Thornton; Charlotte E. Willans

doi:10.1039/C8RA00450A

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

H. A. Mohamed, M. Khuphe, S. J. Boardman, Samantha Shepherd, Roger Phillips, P.D. Thornton, Charlotte E. Willans

University of Leeds

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. Silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

Original language	English
Pages (from-to)	10474-10477
Number of pages	4
Journal	RSC Advances
Volume	8
Issue number	19
Early online date	15 Mar 2018
DOIs	https://doi.org/10.1039/C8RA00450A
Publication status	Published - 2018

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SDG 3 Good Health and Well-being

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Cite this

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title = "Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes",

abstract = "Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. Silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned. ",

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AU - Mohamed, H. A.

AU - Khuphe, M.

AU - Boardman, S. J.

AU - Shepherd, Samantha

AU - Phillips, Roger

AU - Thornton, P.D.

AU - Willans, Charlotte E.

PY - 2018

Y1 - 2018

N2 - Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. Silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

AB - Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. Silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

UR - https://www.scopus.com/pages/publications/85044251171

U2 - 10.1039/C8RA00450A

DO - 10.1039/C8RA00450A

M3 - Article

SN - 2046-2069

VL - 8

SP - 10474

EP - 10477

JO - RSC Advances

JF - RSC Advances

IS - 19

ER -

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Abstract

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