Powder Compaction: Compression Properties of Cellulose Ethers

Research output: Contribution to journalReview article

Abstract

ffective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.
LanguageEnglish
Pages19-29
JournalBritish Journal of Pharmacy
Volume1
Issue number1
DOIs
Publication statusPublished - 14 Nov 2016

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Ethers
Cellulose
Powders
Compaction
Raw materials
Excipients
Tablets
Fabrication
Pharmaceutical Preparations

Cite this

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title = "Powder Compaction: Compression Properties of Cellulose Ethers",
abstract = "ffective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.",
keywords = "Compression, HPMC, Cellulose ethers, Tableting, Matrix tablets, Hydrophilic matrices, Compaction",
author = "Muhammad Ghori and Barbara Conway",
year = "2016",
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day = "14",
doi = "10.5920/bjpharm.2016.09",
language = "English",
volume = "1",
pages = "19--29",
journal = "British Journal of Pharmacy",
issn = "2058-8356",
publisher = "University of Huddersfield Press",
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}

Powder Compaction: Compression Properties of Cellulose Ethers. / Ghori, Muhammad; Conway, Barbara.

In: British Journal of Pharmacy, Vol. 1, No. 1, 14.11.2016, p. 19-29.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Powder Compaction: Compression Properties of Cellulose Ethers

AU - Ghori, Muhammad

AU - Conway, Barbara

PY - 2016/11/14

Y1 - 2016/11/14

N2 - ffective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

AB - ffective development of matrix tablets requires a comprehensive understanding of different raw material attributes and their impact on process parameters. Cellulose ethers (CE) are the most commonly used pharmaceutical excipients in the fabrication of hydrophilic matrices. The innate good compression and binding properties of CE enable matrices to be prepared using economical direct compression (DC) techniques. However, DC is sensitive to raw material attributes, thus, impacting the compaction process. This article critically reviews prior knowledge on the mechanism of powder compaction and the compression properties of cellulose ethers, giving timely insight into new developments in this field.

KW - Compression

KW - HPMC

KW - Cellulose ethers

KW - Tableting

KW - Matrix tablets

KW - Hydrophilic matrices

KW - Compaction

U2 - 10.5920/bjpharm.2016.09

DO - 10.5920/bjpharm.2016.09

M3 - Review article

VL - 1

SP - 19

EP - 29

JO - British Journal of Pharmacy

T2 - British Journal of Pharmacy

JF - British Journal of Pharmacy

SN - 2058-8356

IS - 1

ER -