Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

Simon J. Allison, Gage P. Ashton, Hannah J. Lynch, Bethany R. Shire, Roger M. Phillips, Gareth M.B. Parkes, Emma Pinder, Craig R. Rice, Ana A.M. Teixeira, Tibo Volleman, Daisy A, Wordsworth

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Dipodal pyridylthiazole amine ligands L1 and L2 both form different metallo-supramolecular self-assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.

Original languageEnglish
Article numbere202302803
Number of pages7
JournalChemistry - A European Journal
Issue number3
Early online date21 Nov 2023
Publication statusPublished - 11 Jan 2024

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