@article{613470814afa462f91fd2a15c322f4fd,
title = "Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo",
abstract = "Dipodal pyridylthiazole amine ligands L1 and L2 both form different metallo-supramolecular self-assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.",
keywords = "cancer, cytotoxic, helicate, self-assembly, zinc",
author = "Allison, {Simon J.} and Ashton, {Gage P.} and Lynch, {Hannah J.} and Shire, {Bethany R.} and Phillips, {Roger M.} and Parkes, {Gareth M.B.} and Emma Pinder and Rice, {Craig R.} and Teixeira, {Ana A.M.} and Tibo Volleman and Wordsworth, {Daisy A,}",
note = "Funding Information: This work was funded from generous support from EPSRC (EP/W035251/1). studies were financially supported by a URF award from the University of Huddersfield (to SJA & RMP). In ovo Publisher Copyright: {\textcopyright} 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",
year = "2024",
month = jan,
day = "11",
doi = "10.1002/chem.202302803",
language = "English",
volume = "30",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "3",
}
