Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

Simon J. Allison; Gage P. Ashton; Hannah J. Lynch; Bethany R. Shire; Roger M. Phillips; Gareth M.B. Parkes; Emma Pinder; Craig R. Rice; Ana A.M. Teixeira; Tibo Volleman; Daisy A, Wordsworth

doi:10.1002/chem.202302803

Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

Simon J. Allison, Gage P. Ashton, Hannah J. Lynch, Bethany R. Shire, Roger M. Phillips, Gareth M.B. Parkes, Emma Pinder, Craig R. Rice, Ana A.M. Teixeira, Tibo Volleman, Daisy A, Wordsworth

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Abstract

Dipodal pyridylthiazole amine ligands L¹ and L² both form different metallo-supramolecular self-assemblies with Zn²⁺ and Cu²⁺ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.

Original language	English
Article number	e202302803
Number of pages	7
Journal	Chemistry - A European Journal
Volume	30
Issue number	3
Early online date	21 Nov 2023
DOIs	https://doi.org/10.1002/chem.202302803
Publication status	Published - 11 Jan 2024

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Allison, S. J., Ashton, G. P., Lynch, H. J., Shire, B. R., Phillips, R. M., Parkes, G. M. B., Pinder, E., Rice, C. R., Teixeira, A. A. M., Volleman, T., & Wordsworth, D. A. (2024). Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo. Chemistry - A European Journal, 30(3), Article e202302803. https://doi.org/10.1002/chem.202302803

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title = "Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo",

abstract = "Dipodal pyridylthiazole amine ligands L1 and L2 both form different metallo-supramolecular self-assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.",

keywords = "cancer, cytotoxic, helicate, self-assembly, zinc",

author = "Allison, \{Simon J.\} and Ashton, \{Gage P.\} and Lynch, \{Hannah J.\} and Shire, \{Bethany R.\} and Phillips, \{Roger M.\} and Parkes, \{Gareth M.B.\} and Emma Pinder and Rice, \{Craig R.\} and Teixeira, \{Ana A.M.\} and Tibo Volleman and Wordsworth, \{Daisy A,\}",

note = "Funding Information: This work was funded from generous support from EPSRC (EP/W035251/1). studies were financially supported by a URF award from the University of Huddersfield (to SJA \& RMP). In ovo Publisher Copyright: {\textcopyright} 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.",

year = "2024",

month = jan,

day = "11",

doi = "10.1002/chem.202302803",

language = "English",

volume = "30",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "John Wiley and Sons Inc.",

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}

Allison, SJ , Ashton, GP, Lynch, HJ, Shire, BR , Phillips, RM , Parkes, GMB, Pinder, E, Rice, CR , Teixeira, AAM, Volleman, T & Wordsworth, DA 2024, 'Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo', Chemistry - A European Journal, vol. 30, no. 3, e202302803. https://doi.org/10.1002/chem.202302803

TY - JOUR

T1 - Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

AU - Allison, Simon J.

AU - Ashton, Gage P.

AU - Lynch, Hannah J.

AU - Shire, Bethany R.

AU - Phillips, Roger M.

AU - Parkes, Gareth M.B.

AU - Pinder, Emma

AU - Rice, Craig R.

AU - Teixeira, Ana A.M.

AU - Volleman, Tibo

AU - Wordsworth, Daisy A,

N1 - Funding Information: This work was funded from generous support from EPSRC (EP/W035251/1). studies were financially supported by a URF award from the University of Huddersfield (to SJA & RMP). In ovo Publisher Copyright: © 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.

PY - 2024/1/11

Y1 - 2024/1/11

N2 - Dipodal pyridylthiazole amine ligands L1 and L2 both form different metallo-supramolecular self-assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.

AB - Dipodal pyridylthiazole amine ligands L1 and L2 both form different metallo-supramolecular self-assemblies with Zn2+ and Cu2+ and these are shown to be toxic and selective towards cancer cell lines in vitro. Furthermore, potency and selectivity are highly dependent upon the metal ions, ligand system and bound anion, with significant changes in chemosensitivity and selectivity dependent upon which species are employed. Importantly, significant anti-tumor activity was observed in ovo at doses that are non-toxic.

KW - cancer

KW - cytotoxic

KW - helicate

KW - self-assembly

KW - zinc

UR - https://www.scopus.com/pages/publications/85177420671

U2 - 10.1002/chem.202302803

DO - 10.1002/chem.202302803

M3 - Article

AN - SCOPUS:85177420671

SN - 0947-6539

VL - 30

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 3

M1 - e202302803

ER -

Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo

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