Predictors of invasive mechanical ventilation in hospitalized COVID-19 patients: a retrospective study from Jordan

Suad Kabbaha, Sayer Al-Azzam, Reema A. Karasneh, Basheer Y. Khassawneh, Abdel Hameed Al-Mistarehi, William J. Lattyak, Motasem Aldiab, Syed Shahzad Hasan, Barbara R. Conway, Mamoon A. Aldeyab

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objectives: To identify early indicators for invasive mechanical ventilation utilization among COVID-19 patients. Methods: This retrospective study evaluated COVID-19 patients who were admitted to hospital from 20 September 2020, to 8 August 2021. Multivariable logistic regression and machine learning (ML) methods were employed to assess variable significance. Results: Among 1,613 confirmed COVID-19 patients, 365 patients (22.6%) received invasive mechanical ventilation (IMV). Factors associated with IMV included older age >65 years (OR,1.46; 95%CI, 1.13–1.89), current smoking status (OR, 1.71; 95%CI, 1.22–2.41), critical disease at admission (OR, 1.97; 95%CI, 1.28–3.03), and chronic kidney disease (OR, 2.07; 95%CI, 1.37–3.13). Laboratory abnormalities that were associated with increased risk for IMV included high leukocyte count (OR, 2.19; 95%CI, 1.68–2.87), low albumin (OR, 1.76; 95%CI, 1.33–2.34) and high AST (OR, 1.71; 95%CI, 1.31–2.22). Conclusion: Our study suggests that there are several factors associated with the increased need for IMV among COVID-19 patients. These findings will help in early identification of patients at high risk for IMV and reallocation of hospital resources toward patients who need them the most to improve their outcomes.

Original languageEnglish
Pages (from-to)945-952
Number of pages8
JournalExpert Review of Respiratory Medicine
Issue number8
Early online date8 Aug 2022
Publication statusPublished - 8 Aug 2022


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