Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3mm and bulk densities ranging from 0.11 to 0.23g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria.

Original languageEnglish
Pages (from-to)58-67
Number of pages10
JournalJournal of Microencapsulation
Issue number1
Early online date24 Jun 2013
Publication statusPublished - 1 Jan 2014


Dive into the research topics of 'Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori'. Together they form a unique fingerprint.

Cite this