Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori

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7 Citations (Scopus)

Abstract

There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3mm and bulk densities ranging from 0.11 to 0.23g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria.

LanguageEnglish
Pages58-67
Number of pages10
JournalJournal of Microencapsulation
Volume31
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Alginate
Buoyancy
Helicobacter pylori
beads
Ionotropic gelation
drugs
preparation
Chitosan
Pharmaceutical Preparations
Calcium
Stomach
Bacteria
Coatings
infectious diseases
Drug and Narcotic Control
buoyancy
Metronidazole
Helicobacter Infections
Oils
formulations

Cite this

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abstract = "There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3mm and bulk densities ranging from 0.11 to 0.23g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria.",
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AU - Conway, Barbara R.

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AB - There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3mm and bulk densities ranging from 0.11 to 0.23g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria.

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