Preserving fertility in women with cancer (PreFer): Decision‐ making and patient‐reported outcomes in women offered egg and embryo freezing prior to cancer treatment

Katharina Vogt, Jane Hughes, Anna Wilkinson, Neda Mahmoodi, Jonathan Skull, Hilary Wood, Sophia McDougall, Pauline Slade, Diana M Greenfield, Alan Pacey, William Ledger, Georgina Jones

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective
Women of childbearing age with new cancer diagnoses have to make rapid decisions about fertility preservation (FP) before starting cancer treatment (CT). The aim of the PreFer study was to explore this FP decision‐making process and its impact on patient‐reported outcomes (PROMs) and health‐related quality of life (HRQoL).

Methods
A prospective, mixed‐methods design was used (questionnaires, in‐depth interviews). Interviews were analysed using thematic analysis. Fifty‐eight women with new cancer diagnoses were recruited. Comparisons were made between women who declined FP referral in oncology (Group1) and women who chose referral (Group2). Group 2 was further split into those who had some FP (2A) and those who did not (2B). Questionnaires and PROMs were administered prior to and after the fertility consultation, before the start of CT and 3 months post CT. Interviews were conducted with one participant from Group 2.

Results
HRQoL was negatively affected, particularly depression. Women's lack of understanding about the relationship between CT and fertility were evident. Five themes emerged from the interviews as barriers and facilitators to the FP decision‐making process.

Conclusion
The results indicate that better information and support resources aimed at women to support their decision making are needed, such as patient decision‐aids. Women from Group 1 were found to suffer significantly worse depression compared with the general UK population, highlighting the need for psychological support in the FP care‐pathway and for research exploring the contributions of depression and hopelessness to the decision‐making process.
Original languageEnglish
Pages (from-to)2725-2732
Number of pages8
JournalPsycho-Oncology
Volume27
Issue number12
Early online date24 Aug 2018
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

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  • Cite this

    Vogt, K., Hughes, J., Wilkinson, A., Mahmoodi, N., Skull, J., Wood, H., McDougall, S., Slade, P., M Greenfield, D., Pacey, A., Ledger, W., & Jones, G. (2018). Preserving fertility in women with cancer (PreFer): Decision‐ making and patient‐reported outcomes in women offered egg and embryo freezing prior to cancer treatment. Psycho-Oncology, 27(12), 2725-2732. https://doi.org/10.1002/pon.4866