PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis

Subbroto Kumar Saha, S. M.Riazul Islam, Kyung Sup Kwak, Md. Shahedur Rahman, Ssang Goo Cho

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Prominin 1 (PROM1) is considered a biomarker for cancer stem cells, although its biological role is unclear. Prominin 2 (PROM2) has also been associated with certain cancers. However, the prognostic value of PROM1 and PROM2 in cancer is controversial. Here, we performed a systematic data analysis to examine whether prominins can function as prognostic markers in human cancers. The expression of prominins was assessed and their prognostic value in human cancers was determined using univariate and multivariate survival analyses, via various online platforms. We selected a group of prominent functional protein partners of prominins by protein-protein interaction analysis. Subsequently, we investigated the relationship between mutations and copy number alterations in prominin genes and various types of cancers. Furthermore, we identified genes that correlated with PROM1 and PROM2 in certain cancers, based on their levels of expression. Gene ontology and pathway analyses were performed to assess the effect of these correlated genes on various cancers. We observed that PROM1 was frequently overexpressed in esophageal, liver, and ovarian cancers and its expression was negatively associated with prognosis, whereas PROM2 overexpression was associated with poor overall survival in lung and ovarian cancers. Based on the varying characteristics of prominins, we conclude that PROM1 and PROM2 expression differentially modulates the clinical outcomes of cancers.
Original languageEnglish
Pages (from-to)147-167
Number of pages21
JournalCancer Gene Therapy
Volume27
Issue number3-4
Early online date5 Jun 2019
DOIs
Publication statusPublished - 1 Apr 2020
Externally publishedYes

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