Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer

Xin Liu; Emily K.Y. Lam; Xian Wang; Jianbin Zhang; Yuen Yee Cheng; Yun W. Lam; Enders K.O. Ng; Jun Yu; Francis K.L. Chan; Hongchuan Jin; Joseph J.Y. Sung

doi:10.1159/000243767

Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer

Xin Liu, Emily K.Y. Lam, Xian Wang, Jianbin Zhang, Yuen Yee Cheng, Yun W. Lam, Enders K.O. Ng, Jun Yu, Francis K.L. Chan, Hongchuan Jin, Joseph J.Y. Sung

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development.

Original language	English
Pages (from-to)	242-248
Number of pages	7
Journal	Tumor Biology
Volume	30
Issue number	5-6
Early online date	7 Oct 2009
DOIs	https://doi.org/10.1159/000243767
Publication status	Published - 1 Dec 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000243767Licence: Unspecified

Cite this

@article{2e2f879040f4498d92686a561229439d,

title = "Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer",

abstract = "As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development.",

keywords = "Gastric cancer, Methylation, SLC19A3",

author = "Xin Liu and Lam, {Emily K.Y.} and Xian Wang and Jianbin Zhang and Cheng, {Yuen Yee} and Lam, {Yun W.} and Ng, {Enders K.O.} and Jun Yu and Chan, {Francis K.L.} and Hongchuan Jin and Sung, {Joseph J.Y.}",

year = "2009",

month = dec,

day = "1",

doi = "10.1159/000243767",

language = "English",

volume = "30",

pages = "242--248",

journal = "Oncodevelopmental Biology and Medicine",

issn = "1010-4283",

publisher = "Springer Netherlands",

number = "5-6",

}

TY - JOUR

T1 - Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer

AU - Liu, Xin

AU - Lam, Emily K.Y.

AU - Wang, Xian

AU - Zhang, Jianbin

AU - Cheng, Yuen Yee

AU - Lam, Yun W.

AU - Ng, Enders K.O.

AU - Yu, Jun

AU - Chan, Francis K.L.

AU - Jin, Hongchuan

AU - Sung, Joseph J.Y.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development.

AB - As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development.

KW - Gastric cancer

KW - Methylation

KW - SLC19A3

UR - http://www.scopus.com/inward/record.url?scp=73749088408&partnerID=8YFLogxK

U2 - 10.1159/000243767

DO - 10.1159/000243767

M3 - Article

C2 - 19816091

AN - SCOPUS:73749088408

VL - 30

SP - 242

EP - 248

JO - Oncodevelopmental Biology and Medicine

JF - Oncodevelopmental Biology and Medicine

SN - 1010-4283

IS - 5-6

ER -

Promoter Hypermethylation Mediates Downregulation of Thiamine Receptor SLC19A3 in Gastric Cancer

Abstract

UN SDGs

Access to Document

Other files and links

Cite this