Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

Iain S Haslam, Aaron Pitre, John D Schuetz, Ralf Paus

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.

LanguageEnglish
Pages599-604
Number of pages6
JournalTrends in Pharmacological Sciences
Volume34
Issue number11
Early online date7 Oct 2013
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

Fingerprint

ATP-Binding Cassette Transporters
Chemotherapy
Hair Follicle
Alopecia
Drug Therapy
Cytoplasmic and Nuclear Receptors
Nanoparticles
Neoplasms
Pharmaceutical Preparations
Therapeutics
Epithelium
Pharmacology
Psychology
Technology
Incidence

Cite this

@article{01ae5482ab77420797e96264ace40233,
title = "Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?",
abstract = "Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.",
keywords = "ATP-Binding Cassette Transporters, Alopecia, Animals, Antineoplastic Agents, Hair Follicle, Humans, Mice, Mice, Knockout, Receptors, Cytoplasmic and Nuclear, Journal Article",
author = "Haslam, {Iain S} and Aaron Pitre and Schuetz, {John D} and Ralf Paus",
note = "Copyright {\circledC} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = "11",
doi = "10.1016/j.tips.2013.09.001",
language = "English",
volume = "34",
pages = "599--604",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "11",

}

Protection against chemotherapy-induced alopecia : targeting ATP-binding cassette transporters in the hair follicle? / Haslam, Iain S; Pitre, Aaron; Schuetz, John D; Paus, Ralf.

In: Trends in Pharmacological Sciences, Vol. 34, No. 11, 11.2013, p. 599-604.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protection against chemotherapy-induced alopecia

T2 - Trends in Pharmacological Sciences

AU - Haslam, Iain S

AU - Pitre, Aaron

AU - Schuetz, John D

AU - Paus, Ralf

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.

AB - Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.

KW - ATP-Binding Cassette Transporters

KW - Alopecia

KW - Animals

KW - Antineoplastic Agents

KW - Hair Follicle

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Receptors, Cytoplasmic and Nuclear

KW - Journal Article

UR - http://www.cell.com/trends/pharmacological-sciences/home

U2 - 10.1016/j.tips.2013.09.001

DO - 10.1016/j.tips.2013.09.001

M3 - Article

VL - 34

SP - 599

EP - 604

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 11

ER -