Protein-like Oligomerization of Carbohydrates

Thomas Heinze; Melanie Nikolajski; Stephan Daus; Tabot M D Besong; Nico Michaelis; Peter Berlin; Gordon A. Morris; Arthur J. Rowe; Stephen E. Harding

doi:10.1002/anie.201103026

Protein-like Oligomerization of Carbohydrates

Thomas Heinze, Melanie Nikolajski, Stephan Daus, Tabot M D Besong, Nico Michaelis, Peter Berlin, Gordon A. Morris, Arthur J. Rowe, Stephen E. Harding

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Sugar can, too: Many proteins form noncovalent and thermodynamically reversible oligomers, which can dictate a protein's functionality. For the first time, the presence of multiple oligomeric forms is shown in a whole class of polymeric carbohydrates, the 6-deoxy-6-aminocelluloses, using analytical ultracentrifugation as a probe.

Original language	English
Pages (from-to)	8602-8604
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	37
Early online date	22 Jul 2011
DOIs	https://doi.org/10.1002/anie.201103026
Publication status	Published - 5 Sep 2011
Externally published	Yes

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AU - Heinze, Thomas

AU - Nikolajski, Melanie

AU - Daus, Stephan

AU - Besong, Tabot M D

AU - Michaelis, Nico

AU - Berlin, Peter

AU - Morris, Gordon A.

AU - Rowe, Arthur J.

AU - Harding, Stephen E.

PY - 2011/9/5

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AB - Sugar can, too: Many proteins form noncovalent and thermodynamically reversible oligomers, which can dictate a protein's functionality. For the first time, the presence of multiple oligomeric forms is shown in a whole class of polymeric carbohydrates, the 6-deoxy-6-aminocelluloses, using analytical ultracentrifugation as a probe.

KW - Aminocellulose

KW - Analytical ultracentrifugation

KW - Carbohydrates

KW - Nanobiotechnology

KW - Self-assembly

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UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 37

ER -

Protein-like Oligomerization of Carbohydrates

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