Protein moonlighting in parasitic protists

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Reductive evolution during the adaptation to obligate parasitism and expansions of gene families encoding virulence factors are characteristics evident to greater or lesser degrees in all parasitic protists studied to date. Large evolutionary distances separate many parasitic protists from the yeast and animal models upon which classic views of eukaryotic biochemistry are often based. Thus a combination of evolutionary divergence, niche adaptation and reductive evolution means the biochemistry of parasitic protists is often very different from their hosts and to other eukaryotes generally, making parasites intriguing subjects for those interested in the phenomenon of moonlighting proteins. In common with other organisms, the contribution of protein moonlighting to parasite biology is only just emerging, and it is not without controversy. Here, an overview of recently identified moonlighting proteins in parasitic protists is provided, together with discussion of some of the controversies.

LanguageEnglish
Pages1734-1739
Number of pages6
JournalBiochemical Society Transactions
Volume42
Issue number6
Early online date17 Nov 2014
DOIs
Publication statusPublished - Dec 2014
Externally publishedYes

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Biochemistry
Parasites
Proteins
Virulence Factors
Eukaryota
Yeast
Animals
Animal Models
Genes
Yeasts

Cite this

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Protein moonlighting in parasitic protists. / Ginger, Michael L.

In: Biochemical Society Transactions, Vol. 42, No. 6, 12.2014, p. 1734-1739.

Research output: Contribution to journalArticle

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