Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients

Mamoon A. Aldeyab, Stephan Harbarth, Nathalie Vernaz, Mary P. Kearney, Michael G. Scott, Chris Funston, Karen Savage, Denise Kelly, Motasem A. Aldiab, James C. McElnay

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The objective of this study was to evaluate the effects of antimicrobial drug use, gastric acid-suppressive agent use, and infection control practices on the incidence of Clostridium difficile-associated diarrhea (CDAD) in a 426-bed general teaching hospital in Northern Ireland. The study was retrospective and ecological in design. A multivariate autoregressive integrated moving average (time-series analysis) model was built to relate CDAD incidence with antibiotic use, gastric acid-suppressive agent use, and infection control practices within the hospital over a 5-year period (February 2002 to March 2007). The findings of this study showed that temporal variation in CDAD incidence followed temporal variations in expanded-spectrum cephalosporin use (average delay = 2 months; variation of CDAD incidence = 0.01/100 bed-days), broad-spectrum cephalosporin use (average delay = 2 months; variation of CDAD incidence = 0.02/100 bed-days), fluoroquinolone use (average delay = 3 months; variation of CDAD incidence = 0.004/100 bed-days), amoxicillin-clavulanic acid use (average delay = 1 month; variation of CDAD incidence = 0.002/100 bed-days), and macrolide use (average delay = 5 months; variation of CDAD incidence = 0.002/100 bed-days). Temporal relationships were also observed between CDAD incidence and use of histamine-2 receptor antagonists (H2RAs; average delay = 1 month; variation of CDAD incidence = 0.001/100 bed-days). The model explained 78% of the variance in the monthly incidence of CDAD. The findings of this study highlight a temporal relationship between certain classes of antibiotics, H2RAs, and CDAD incidence. The results of this research can help hospitals to set priorities for restricting the use of specific antibiotic classes, based on the size-effect of each class and the delay necessary to observe an effect.

LanguageEnglish
Pages2082-2088
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number5
DOIs
Publication statusPublished - 1 May 2009
Externally publishedYes

Fingerprint

Clostridium difficile
Gastric Acid
Infection Control
Diarrhea
Anti-Bacterial Agents
Incidence
Cephalosporins
Histamine Receptors
Amoxicillin-Potassium Clavulanate Combination
Northern Ireland
Fluoroquinolones
Macrolides
Teaching Hospitals
General Hospitals
Retrospective Studies

Cite this

Aldeyab, Mamoon A. ; Harbarth, Stephan ; Vernaz, Nathalie ; Kearney, Mary P. ; Scott, Michael G. ; Funston, Chris ; Savage, Karen ; Kelly, Denise ; Aldiab, Motasem A. ; McElnay, James C. / Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients. In: Antimicrobial Agents and Chemotherapy. 2009 ; Vol. 53, No. 5. pp. 2082-2088.
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abstract = "The objective of this study was to evaluate the effects of antimicrobial drug use, gastric acid-suppressive agent use, and infection control practices on the incidence of Clostridium difficile-associated diarrhea (CDAD) in a 426-bed general teaching hospital in Northern Ireland. The study was retrospective and ecological in design. A multivariate autoregressive integrated moving average (time-series analysis) model was built to relate CDAD incidence with antibiotic use, gastric acid-suppressive agent use, and infection control practices within the hospital over a 5-year period (February 2002 to March 2007). The findings of this study showed that temporal variation in CDAD incidence followed temporal variations in expanded-spectrum cephalosporin use (average delay = 2 months; variation of CDAD incidence = 0.01/100 bed-days), broad-spectrum cephalosporin use (average delay = 2 months; variation of CDAD incidence = 0.02/100 bed-days), fluoroquinolone use (average delay = 3 months; variation of CDAD incidence = 0.004/100 bed-days), amoxicillin-clavulanic acid use (average delay = 1 month; variation of CDAD incidence = 0.002/100 bed-days), and macrolide use (average delay = 5 months; variation of CDAD incidence = 0.002/100 bed-days). Temporal relationships were also observed between CDAD incidence and use of histamine-2 receptor antagonists (H2RAs; average delay = 1 month; variation of CDAD incidence = 0.001/100 bed-days). The model explained 78{\%} of the variance in the monthly incidence of CDAD. The findings of this study highlight a temporal relationship between certain classes of antibiotics, H2RAs, and CDAD incidence. The results of this research can help hospitals to set priorities for restricting the use of specific antibiotic classes, based on the size-effect of each class and the delay necessary to observe an effect.",
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Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients. / Aldeyab, Mamoon A.; Harbarth, Stephan; Vernaz, Nathalie; Kearney, Mary P.; Scott, Michael G.; Funston, Chris; Savage, Karen; Kelly, Denise; Aldiab, Motasem A.; McElnay, James C.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 5, 01.05.2009, p. 2082-2088.

Research output: Contribution to journalArticle

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AU - Funston, Chris

AU - Savage, Karen

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AU - McElnay, James C.

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