Raft-forming Polysaccharides for the Treatment of Gastroesophageal Reflux Disease (GORD): Systematic Review

Maria Yousaf, Jorabar Nirwan, Alan Smith, Peter Timmins, Barbara Conway, Muhammad Usman Ghori

Research output: Contribution to journalReview article

Abstract

Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft-forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam-like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta-analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft-forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft-forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft-forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti-reflux raft-forming formulations.

Original languageEnglish
Article number48012
Number of pages24
JournalJournal of Applied Polymer Science
Volume136
Issue number40
Early online date4 Jun 2019
DOIs
Publication statusPublished - 20 Oct 2019

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