Raft-forming Polysaccharides for the Treatment of Gastroesophageal Reflux Disease (GORD): Systematic Review

Maria Yousaf, Jorabar Nirwan, Alan Smith, Peter Timmins, Barbara Conway, Muhammad Usman Ghori

Research output: Contribution to journalReview article

Abstract

Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft-forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam-like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta-analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft-forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft-forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft-forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti-reflux raft-forming formulations.

LanguageEnglish
Article number48012
Number of pages24
JournalJournal of Applied Polymer Science
Volume136
Issue number40
Early online date4 Jun 2019
DOIs
Publication statusE-pub ahead of print - 4 Jun 2019

Fingerprint

Polysaccharides
Polymers
Psyllium
Xanthan gum
Alginate
Drug products
Foams
Acids
Fibers
Testing
Pharmaceutical Preparations

Cite this

@article{d479efdd20af4d5c999e2105ebdf1dd0,
title = "Raft-forming Polysaccharides for the Treatment of Gastroesophageal Reflux Disease (GORD): Systematic Review",
abstract = "Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft-forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam-like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta-analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft-forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft-forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft-forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti-reflux raft-forming formulations.",
keywords = "gastroesophageal reflux disease, raft formulations, raft-forming agents, reflux, systematic review",
author = "Maria Yousaf and Jorabar Nirwan and Alan Smith and Peter Timmins and Barbara Conway and Ghori, {Muhammad Usman}",
year = "2019",
month = "6",
day = "4",
doi = "10.1002/app.48012",
language = "English",
volume = "136",
journal = "Journal of Applied Polymer Science",
issn = "0021-8995",
publisher = "John Wiley and Sons Inc.",
number = "40",

}

Raft-forming Polysaccharides for the Treatment of Gastroesophageal Reflux Disease (GORD): Systematic Review. / Yousaf, Maria; Nirwan, Jorabar; Smith, Alan; Timmins, Peter; Conway, Barbara; Ghori, Muhammad Usman .

In: Journal of Applied Polymer Science, Vol. 136, No. 40, 48012, 20.10.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Raft-forming Polysaccharides for the Treatment of Gastroesophageal Reflux Disease (GORD): Systematic Review

AU - Yousaf, Maria

AU - Nirwan, Jorabar

AU - Smith, Alan

AU - Timmins, Peter

AU - Conway, Barbara

AU - Ghori, Muhammad Usman

PY - 2019/6/4

Y1 - 2019/6/4

N2 - Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft-forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam-like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta-analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft-forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft-forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft-forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti-reflux raft-forming formulations.

AB - Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft-forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam-like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta-analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft-forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft-forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft-forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti-reflux raft-forming formulations.

KW - gastroesophageal reflux disease

KW - raft formulations

KW - raft-forming agents

KW - reflux

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85067067321&partnerID=8YFLogxK

U2 - 10.1002/app.48012

DO - 10.1002/app.48012

M3 - Review article

VL - 136

JO - Journal of Applied Polymer Science

T2 - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

SN - 0021-8995

IS - 40

M1 - 48012

ER -