Randomized controlled trial comparing the combination of a polymeric membrane dressing plus negative pressure wound therapy against negative pressure wound therapy alone

The WICVAC study

Edda Skrinjar, Nikolaus Duschek, Gottfried S. Bayer, Ojan Assadian, Spyridon Koulas, Kornelia Hirsch, Jelena Basic, Afshin Assadian

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Negative pressure wound therapy (NPWT) is the treatment of choice for chronic wounds; yet, it is associated with considerable workload. Prompted by its nonadhesive and wound-healing properties, this study investigated the effect of an additional polymeric membrane interface dressing (PMD; PolyMem WIC) in NPWT. From October 2011 to April 2013, 60 consecutive patients with chronic leg wounds or surgical site infections after revascularization of lower extremities were randomly allocated to either treatment with conventional NPWT (control arm) or NPWT with an additional PMD (intervention arm). The primary outcome was wound healing achieved within 30 days, the secondary endpoints included: number of days between dressing changes, wound-related pain, cost efficiency, and occurrence of adverse events (ClinTrials.gov Identifier: NCT02399722). Forty-seven patients completed follow-up. No difference in wound healing was observed (p > 0.05) between both study arms. The additional PMD allowed significantly longer wearing times (days) between dressing changes (intervention: 8.8 ± 0.5, control: 4.8 ± 0.2; p < 0.001). Pain was slightly higher in patients randomized to NPWT alone (VAS score: 4.8 ± 2.9) compared to NPWT + PMD (VAS score: 3.0 ± 2.9, p = 0.063). No wound infections were observed. Costs were reduced by 34% per patient in the intervention arm. These results suggest that the combination of NPWT and an additional interface PMD is a safe and economic method for the treatment of chronic wounds, which requires significantly fewer dressing changes for a comparable wound healing.

Original languageEnglish
Pages (from-to)928-935
Number of pages8
JournalWound Repair and Regeneration
Volume24
Issue number5
Early online date16 Jun 2016
DOIs
Publication statusPublished - Sep 2016

Fingerprint

Negative-Pressure Wound Therapy
Bandages
Randomized Controlled Trials
Membranes
Wound Healing
Arm
Wounds and Injuries
Surgical Wound Infection
Costs and Cost Analysis
Pain
Wound Infection
Workload
Lower Extremity
Leg
Therapeutics
Economics

Cite this

Skrinjar, Edda ; Duschek, Nikolaus ; Bayer, Gottfried S. ; Assadian, Ojan ; Koulas, Spyridon ; Hirsch, Kornelia ; Basic, Jelena ; Assadian, Afshin. / Randomized controlled trial comparing the combination of a polymeric membrane dressing plus negative pressure wound therapy against negative pressure wound therapy alone : The WICVAC study. In: Wound Repair and Regeneration. 2016 ; Vol. 24, No. 5. pp. 928-935.
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Randomized controlled trial comparing the combination of a polymeric membrane dressing plus negative pressure wound therapy against negative pressure wound therapy alone : The WICVAC study. / Skrinjar, Edda; Duschek, Nikolaus; Bayer, Gottfried S.; Assadian, Ojan; Koulas, Spyridon; Hirsch, Kornelia; Basic, Jelena; Assadian, Afshin.

In: Wound Repair and Regeneration, Vol. 24, No. 5, 09.2016, p. 928-935.

Research output: Contribution to journalArticle

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AU - Duschek, Nikolaus

AU - Bayer, Gottfried S.

AU - Assadian, Ojan

AU - Koulas, Spyridon

AU - Hirsch, Kornelia

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AU - Assadian, Afshin

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