Re: COVID vaccines and thrombotic events: Is mRNA translation and spike protein synthesis by platelets a real possibility?

Research output: Contribution to journalLetterpeer-review

Abstract

This is in response to the comments from Professor Paolo Gresele on our rapid response, ‘CoViD Vaccines and thrombotic events: Possibility of mRNA translation and spike protein synthesis by platelets?’ There is evidence to suggest that viruses like Dengue, influenza, and HIV can infect platelets, and there is a preliminary evidence of the presence of SARS-CoV-2 in the platelets in CoViD-19 patients. The term ‘genetic vaccines’ also include mRNA based CoViD-19 vaccines; it is likely that mRNA vaccines can directly infect platelets and mRNA translation and spike protein synthesis leading to an autoimmune response against platelets. The viral vector CoViD-19 vaccines may still infect megakaryocytes, the precursor cells for platelets. The platelets have a very short life span (~10 days) and an autoimmune destruction of megakaryocytes may lead to a severe thrombocytopaenia. The viral particles are unlikely to be confined to the muscles at the injection site; they are free to distribute across the body and drain through lymphatic system; their apparent volume of distribution is likely to be very high. Recently, scientists from Oslo identified an antibody from vaccinated individuals which they suspect being responsible for attacking platelets and causing recent thrombotic events [11]. This discovery also supports our hypothesis [2] that CoViD genetic vaccines may have a direct role in spurring autoimmune response against platelets that may clinically manifest in thrombocytopenia, haemorrhage, and blood clots.
Original languageEnglish
Article numberbmj.n699/rr-20
Number of pages1
JournalThe BMJ
Publication statusE-pub ahead of print - 20 Mar 2021

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