Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Karen J. Davies, Michael I. Page

Research output: Contribution to journalArticle

7 Citations (Scopus)


The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.

Original languageEnglish
Pages (from-to)1448-1450
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number20
Publication statusPublished - 15 Oct 1990


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