Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Karen J. Davies, Michael I. Page

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.

LanguageEnglish
Pages1448-1450
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number20
DOIs
Publication statusPublished - 15 Oct 1990

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Cephalosporins
Thermodynamics
Reaction rates
Protons
Ions
Acids

Cite this

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abstract = "The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.",
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Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates : The Alcoholysis of Cephalosporins . / Davies, Karen J.; Page, Michael I.

In: Journal of the Chemical Society, Chemical Communications, No. 20, 15.10.1990, p. 1448-1450.

Research output: Contribution to journalArticle

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