Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Karen J. Davies; Michael I. Page

doi:10.1039/C39900001448

Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Karen J. Davies, Michael I. Page

School of Applied Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T^-) by proton donors to give the thermodynamically more stable neutral intermediate T^o at a rate which is faster than breakdown of T^-.

Original language	English
Pages (from-to)	1448-1450
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	20
DOIs	https://doi.org/10.1039/C39900001448
Publication status	Published - 15 Oct 1990

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title = "Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins ",

abstract = "The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.",

author = "Davies, \{Karen J.\} and Page, \{Michael I.\}",

year = "1990",

month = oct,

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doi = "10.1039/C39900001448",

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journal = "Journal of the Chemical Society, Chemical Communications",

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T1 - Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates

T2 - The Alcoholysis of Cephalosporins

AU - Davies, Karen J.

AU - Page, Michael I.

PY - 1990/10/15

Y1 - 1990/10/15

N2 - The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.

AB - The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.

UR - https://www.scopus.com/pages/publications/0025155828

U2 - 10.1039/C39900001448

DO - 10.1039/C39900001448

M3 - Article

AN - SCOPUS:0025155828

SN - 0022-4936

SP - 1448

EP - 1450

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 20

ER -

Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Abstract

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