Abstract
The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T-) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T-.
| Original language | English |
|---|---|
| Pages (from-to) | 1448-1450 |
| Number of pages | 3 |
| Journal | Journal of the Chemical Society, Chemical Communications |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 15 Oct 1990 |
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