Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

Christopher Dunnill, Thomas Patton, James Brennan, John Barrett, Matthew Dryden, Jonathan Cooke, David Leaper, Nikolaos T. Georgopoulos

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

LanguageEnglish
Pages89-96
Number of pages8
JournalInternational Wound Journal
Volume14
Issue number1
Early online date21 Dec 2015
DOIs
Publication statusPublished - Feb 2017

Fingerprint

Wound Healing
Reactive Oxygen Species
Technology
Wounds and Injuries
Leg Ulcer
Diabetic Foot
Pressure Ulcer
Wound Infection
Phagocytes
Infection Control
Blood Vessels
Perfusion
Lymphocytes

Cite this

@article{ecf69878b90f4a6faf0fe379a7230e47,
title = "Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process",
abstract = "Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.",
keywords = "Host defence, Reactive oxygen species, Wound healing, Wound infection",
author = "Christopher Dunnill and Thomas Patton and James Brennan and John Barrett and Matthew Dryden and Jonathan Cooke and David Leaper and Georgopoulos, {Nikolaos T.}",
note = "Accepted Nov 2015 Epub Dec 2015 - HN 27/10/2017",
year = "2017",
month = "2",
doi = "10.1111/iwj.12557",
language = "English",
volume = "14",
pages = "89--96",
journal = "International Wound Journal",
issn = "1742-4801",
publisher = "Wiley",
number = "1",

}

Reactive oxygen species (ROS) and wound healing : the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. / Dunnill, Christopher; Patton, Thomas; Brennan, James; Barrett, John; Dryden, Matthew; Cooke, Jonathan; Leaper, David; Georgopoulos, Nikolaos T.

In: International Wound Journal, Vol. 14, No. 1, 02.2017, p. 89-96.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reactive oxygen species (ROS) and wound healing

T2 - International Wound Journal

AU - Dunnill, Christopher

AU - Patton, Thomas

AU - Brennan, James

AU - Barrett, John

AU - Dryden, Matthew

AU - Cooke, Jonathan

AU - Leaper, David

AU - Georgopoulos, Nikolaos T.

N1 - Accepted Nov 2015 Epub Dec 2015 - HN 27/10/2017

PY - 2017/2

Y1 - 2017/2

N2 - Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

AB - Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

KW - Host defence

KW - Reactive oxygen species

KW - Wound healing

KW - Wound infection

UR - http://www.scopus.com/inward/record.url?scp=85008392511&partnerID=8YFLogxK

U2 - 10.1111/iwj.12557

DO - 10.1111/iwj.12557

M3 - Article

VL - 14

SP - 89

EP - 96

JO - International Wound Journal

JF - International Wound Journal

SN - 1742-4801

IS - 1

ER -