Recent developments in microbial metabolic engineering for the production of 1,3-propanediol

Bao Guang Wang, Ming Liu, Chen Yu Du, Jin Yu Shen, Zhu An Cao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Integration of metabolic engineering and fermentation production technologies is necessary for the successful commercial production of chemicals. For the case of biological production of 1,3-propanediol with glycerol, the natural strains are utilized to produce 1,3-propanediol, but the by-products inhibit the product yield for consuming reducing equivalents, however by means of metabolic engineering, this problem can be solved. Besides, by means of utilizing genes from natural strains that produce 1,3-propanediol from glycerol, a recombinant strain that utilizes the cheaper feedstock glucose can be realized, it will increase the competitiveness of the biological production of 1,3-propanediol. In this article, the metabolic engineerings of the glycerol pathway and glucose pathway are reviewed respectively, as well as the recent developments and new trends.

LanguageEnglish
Pages144-149
Number of pages6
JournalGuocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering
Volume6
Issue number1
Publication statusPublished - 1 Feb 2006
Externally publishedYes

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Metabolic engineering
Glycerol
Glucose
Fermentation
Feedstocks
Byproducts
Genes
1,3-propanediol

Cite this

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abstract = "Integration of metabolic engineering and fermentation production technologies is necessary for the successful commercial production of chemicals. For the case of biological production of 1,3-propanediol with glycerol, the natural strains are utilized to produce 1,3-propanediol, but the by-products inhibit the product yield for consuming reducing equivalents, however by means of metabolic engineering, this problem can be solved. Besides, by means of utilizing genes from natural strains that produce 1,3-propanediol from glycerol, a recombinant strain that utilizes the cheaper feedstock glucose can be realized, it will increase the competitiveness of the biological production of 1,3-propanediol. In this article, the metabolic engineerings of the glycerol pathway and glucose pathway are reviewed respectively, as well as the recent developments and new trends.",
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Recent developments in microbial metabolic engineering for the production of 1,3-propanediol. / Wang, Bao Guang; Liu, Ming; Du, Chen Yu; Shen, Jin Yu; Cao, Zhu An.

In: Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering, Vol. 6, No. 1, 01.02.2006, p. 144-149.

Research output: Contribution to journalArticle

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