Reconciling migration models to the Americas with the variation of North American native mitogenomes

Alessandro Achilli, Ugo A. Perego, Hovirag Lancioni, Anna Olivieri, Francesca Gandini, Baharak Hooshiar Kashani, Vincenza Battaglia, Viola Grugni, Norman Angerhofer, Mary P. Rogers, Rene J. Herrera, Scott R. Woodward, Damian Labuda, David Glenn Smith, Jerome S. Cybulski, Ornella Semino, Ripan S. Malhi, Antonio Torroni

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Abstract

In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ~11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic.

LanguageEnglish
Pages14308-14313
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number35
DOIs
Publication statusPublished - 27 Aug 2013
Externally publishedYes

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Mitochondrial Genome
North American Indians
Inuits
North America
Canada
Greenland
Gene Pool
Gene Flow
Population Dynamics
Mitochondrial DNA
Mothers

Cite this

Achilli, Alessandro ; Perego, Ugo A. ; Lancioni, Hovirag ; Olivieri, Anna ; Gandini, Francesca ; Kashani, Baharak Hooshiar ; Battaglia, Vincenza ; Grugni, Viola ; Angerhofer, Norman ; Rogers, Mary P. ; Herrera, Rene J. ; Woodward, Scott R. ; Labuda, Damian ; Smith, David Glenn ; Cybulski, Jerome S. ; Semino, Ornella ; Malhi, Ripan S. ; Torroni, Antonio. / Reconciling migration models to the Americas with the variation of North American native mitogenomes. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 35. pp. 14308-14313.
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abstract = "In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ~11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic.",
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Achilli, A, Perego, UA, Lancioni, H, Olivieri, A, Gandini, F, Kashani, BH, Battaglia, V, Grugni, V, Angerhofer, N, Rogers, MP, Herrera, RJ, Woodward, SR, Labuda, D, Smith, DG, Cybulski, JS, Semino, O, Malhi, RS & Torroni, A 2013, 'Reconciling migration models to the Americas with the variation of North American native mitogenomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 35, pp. 14308-14313. https://doi.org/10.1073/pnas.1306290110

Reconciling migration models to the Americas with the variation of North American native mitogenomes. / Achilli, Alessandro; Perego, Ugo A.; Lancioni, Hovirag; Olivieri, Anna; Gandini, Francesca; Kashani, Baharak Hooshiar; Battaglia, Vincenza; Grugni, Viola; Angerhofer, Norman; Rogers, Mary P.; Herrera, Rene J.; Woodward, Scott R.; Labuda, Damian; Smith, David Glenn; Cybulski, Jerome S.; Semino, Ornella; Malhi, Ripan S.; Torroni, Antonio.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 35, 27.08.2013, p. 14308-14313.

Research output: Contribution to journalArticle

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T1 - Reconciling migration models to the Americas with the variation of North American native mitogenomes

AU - Achilli, Alessandro

AU - Perego, Ugo A.

AU - Lancioni, Hovirag

AU - Olivieri, Anna

AU - Gandini, Francesca

AU - Kashani, Baharak Hooshiar

AU - Battaglia, Vincenza

AU - Grugni, Viola

AU - Angerhofer, Norman

AU - Rogers, Mary P.

AU - Herrera, Rene J.

AU - Woodward, Scott R.

AU - Labuda, Damian

AU - Smith, David Glenn

AU - Cybulski, Jerome S.

AU - Semino, Ornella

AU - Malhi, Ripan S.

AU - Torroni, Antonio

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N2 - In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ~11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic.

AB - In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ~11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic.

KW - Human mtDNA

KW - Native Americans

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