This article charts the response of social work educators in addressing HIV-AIDS. Based at the University of the West Indies in the Republic of Trinidad and Tobago, the faculty within the Social Work Unit developed a model of teaching, research and practice that was innovative and transcended cultural, geographical and professional boundaries. The model has contributed a lasting legacy of knowledge and culturally relevant practices to enhance the capacity and effectiveness of social workers working with people living with HIV-AIDS (PLWHIV). Inherent in the propositions that underpinned the model was a belief in the role of education in alleviating psychosocial and other impacts of social problems. This article describes this unique initiative and discusses its relevance to current social work practice and the implications for contemporary social work education. The authors argue that while social work draws on a common body of knowledge, an established set of professional skills and a universal code of values, these central tenets of the profession should not be regarded as concrete and fixed but must be figured and reconfigured as needed to address emerging contemporary problems and their specific sociocultural manifestations.