In countries across the world, the COVID-19 global health crisis is one of the biggest challenges humanity has faced in recent times. There have been economic, social, political and cultural challenges in all parts of society. Drastic measures have had to be put in place, with many countries injecting extra investment into the health sector and generating support for people who cannot work due to the lockdown rules that have been implemented. The coronavirus pandemic has forced institutions to rethink how the government state functions. Various institutions, from charities and non-government organizations, to the public/private sectors, are the driving forces in tackling this pandemic. Social entrepreneurship is seen as a shining light to public policymakers in these new times, as social entrepreneurship is considered a greater innovator for solutions. The focus of this paper is to critically explore the importance of social entrepreneurial leadership in this new COVID-19 era. In this paper, the authors argue for a rethinking of the connections between social entrepreneurship and leadership and management.