Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter

Peter R Joyce; Patrick C McHugh; Katrina J Light; Sarah Rowe; Allison L Miller; Martin A Kennedy

doi:10.1016/j.biopsych.2009.03.005

Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter

Peter R Joyce, Patrick C McHugh, Katrina J Light, Sarah Rowe, Allison L Miller, Martin A Kennedy

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.

METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.

RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.

CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.

Original language	English
Pages (from-to)	717-21
Number of pages	5
Journal	Biological Psychiatry
Volume	66
Issue number	8
DOIs	https://doi.org/10.1016/j.biopsych.2009.03.005
Publication status	Published - 15 Oct 2009

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@article{f83ec0806059497aacbe16186db1c638,

title = "Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter",

abstract = "BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.",

keywords = "Alleles, Anger, Borderline Personality Disorder/psychology, Dopamine Plasma Membrane Transport Proteins/genetics, Female, Humans, Impulsive Behavior/genetics, Male, Middle Aged, Mood Disorders/diagnosis, Personality/genetics, Polymorphism, Genetic",

author = "Joyce, {Peter R} and McHugh, {Patrick C} and Light, {Katrina J} and Sarah Rowe and Miller, {Allison L} and Kennedy, {Martin A}",

year = "2009",

month = oct,

day = "15",

doi = "10.1016/j.biopsych.2009.03.005",

language = "English",

volume = "66",

pages = "717--21",

journal = "Biological Psychiatry",

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T1 - Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter

AU - Joyce, Peter R

AU - McHugh, Patrick C

AU - Light, Katrina J

AU - Rowe, Sarah

AU - Miller, Allison L

AU - Kennedy, Martin A

PY - 2009/10/15

Y1 - 2009/10/15

N2 - BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.

AB - BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.

KW - Alleles

KW - Anger

KW - Borderline Personality Disorder/psychology

KW - Dopamine Plasma Membrane Transport Proteins/genetics

KW - Female

KW - Humans

KW - Impulsive Behavior/genetics

KW - Male

KW - Middle Aged

KW - Mood Disorders/diagnosis

KW - Personality/genetics

KW - Polymorphism, Genetic

U2 - 10.1016/j.biopsych.2009.03.005

DO - 10.1016/j.biopsych.2009.03.005

M3 - Article

C2 - 19368898

VL - 66

SP - 717

EP - 721

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 8

ER -

Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter

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