Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter

Peter R Joyce, Patrick C McHugh, Katrina J Light, Sarah Rowe, Allison L Miller, Martin A Kennedy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.

METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.

RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.

CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.

LanguageEnglish
Pages717-21
Number of pages5
JournalBiological Psychiatry
Volume66
Issue number8
DOIs
Publication statusPublished - 15 Oct 2009

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Dopamine Plasma Membrane Transport Proteins
Genetic Polymorphisms
Borderline Personality Disorder
Personality
Mood Disorders
Alleles
Odds Ratio
Minisatellite Repeats
Molecular Biology
Depression

Cite this

Joyce, Peter R ; McHugh, Patrick C ; Light, Katrina J ; Rowe, Sarah ; Miller, Allison L ; Kennedy, Martin A. / Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. In: Biological Psychiatry. 2009 ; Vol. 66, No. 8. pp. 717-21.
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Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. / Joyce, Peter R; McHugh, Patrick C; Light, Katrina J; Rowe, Sarah; Miller, Allison L; Kennedy, Martin A.

In: Biological Psychiatry, Vol. 66, No. 8, 15.10.2009, p. 717-21.

Research output: Contribution to journalArticle

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N2 - BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients.METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality.RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD.CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.

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