Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery

Valeria Araujo, Alexander Gamboa, Nelson Caro, Lilian Abugoch, Martin Gotteland, Fernando Valenzuela, Hamid A Merchant, Abdul W Basit, Cristián Tapia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Putative colonic release formulations of calcium (Ca)-alginate coated with chitosan containing two different actives, prednisolone and inulin, were prepared in three different sizes, beads (D50 = 2104 μm) and microparticles (D50 = 354 and 136 μm). The formulations were tested in standard phosphate buffer and biorelevant Krebs bicarbonate buffer at pH 7.4, and were further evaluated in the presence of the bacterium E. coli. Product yield and encapsulation were higher with prednisolone than with inulin. In Krebs bicarbonate buffer, a clear relationship between particle size and prednisolone release was observed. In contrast, release of inulin was independent of the particle size. In phosphate buffer, the particles eroded quickly, whereas in Krebs buffer, the particles swelled slowly. The difference in behavior can be attributed to the formation of calcium phosphate in the phosphate buffer medium, which in turn weakens the Ca-alginate matrix core. In the presence of E. coli, the formulations were fermented and the release of prednisolone was accelerated. In conclusion, the buffer media affects formulation behavior and drug release, with the bicarbonate media providing a better simulation of in vivo behavior. Moreover, the susceptibility of the formulations to bacterial action indicates their suitability as carriers for colonic drug delivery.

LanguageEnglish
Pages2748-2759
Number of pages12
JournalJournal of Pharmaceutical Sciences
Volume102
Issue number8
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

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Inulin
Chitosan
Prednisolone
Buffers
Bicarbonates
Phosphates
Particle Size
Escherichia coli
Drug Carriers
alginic acid
Bacteria

Cite this

Araujo, V., Gamboa, A., Caro, N., Abugoch, L., Gotteland, M., Valenzuela, F., ... Tapia, C. (2013). Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery. Journal of Pharmaceutical Sciences, 102(8), 2748-2759. https://doi.org/10.1002/jps.23656
Araujo, Valeria ; Gamboa, Alexander ; Caro, Nelson ; Abugoch, Lilian ; Gotteland, Martin ; Valenzuela, Fernando ; Merchant, Hamid A ; Basit, Abdul W ; Tapia, Cristián. / Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery. In: Journal of Pharmaceutical Sciences. 2013 ; Vol. 102, No. 8. pp. 2748-2759.
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Araujo, V, Gamboa, A, Caro, N, Abugoch, L, Gotteland, M, Valenzuela, F, Merchant, HA, Basit, AW & Tapia, C 2013, 'Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery', Journal of Pharmaceutical Sciences, vol. 102, no. 8, pp. 2748-2759. https://doi.org/10.1002/jps.23656

Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery. / Araujo, Valeria; Gamboa, Alexander; Caro, Nelson; Abugoch, Lilian; Gotteland, Martin; Valenzuela, Fernando; Merchant, Hamid A; Basit, Abdul W; Tapia, Cristián.

In: Journal of Pharmaceutical Sciences, Vol. 102, No. 8, 08.2013, p. 2748-2759.

Research output: Contribution to journalArticle

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AU - Araujo, Valeria

AU - Gamboa, Alexander

AU - Caro, Nelson

AU - Abugoch, Lilian

AU - Gotteland, Martin

AU - Valenzuela, Fernando

AU - Merchant, Hamid A

AU - Basit, Abdul W

AU - Tapia, Cristián

N1 - Copyright © 2013 Wiley Periodicals, Inc.

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KW - Drug Carriers/chemistry

KW - Escherichia coli/physiology

KW - Glucuronic Acid/chemistry

KW - Hexuronic Acids/chemistry

KW - Humans

KW - Hydrogels/chemistry

KW - Inulin/administration & dosage

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KW - Prednisolone/administration & dosage

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