Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer

Ralph W. Adams, Juan A. Aguilar, Kevin D. Atkinson, Michael J. Cowley, Paul I P Elliott, Simon B. Duckett, Gary G R Green, Iman G. Khazal, Joaquin Lopez-Serrano, David C. Williamson

Research output: Contribution to journalArticle

419 Citations (Scopus)

Abstract

The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.

LanguageEnglish
Pages1708-1711
Number of pages4
JournalScience
Volume323
Issue number5922
DOIs
Publication statusPublished - 27 Mar 2009
Externally publishedYes

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Hydrogenation
Hydrogen
Coordination Complexes
Magnetic Fields
Protons
Magnetic Resonance Spectroscopy
Nitrogen
Carbon
Magnetic Resonance Imaging
Population

Cite this

Adams, R. W., Aguilar, J. A., Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., ... Williamson, D. C. (2009). Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. Science, 323(5922), 1708-1711. https://doi.org/10.1126/science.1168877
Adams, Ralph W. ; Aguilar, Juan A. ; Atkinson, Kevin D. ; Cowley, Michael J. ; Elliott, Paul I P ; Duckett, Simon B. ; Green, Gary G R ; Khazal, Iman G. ; Lopez-Serrano, Joaquin ; Williamson, David C. / Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. In: Science. 2009 ; Vol. 323, No. 5922. pp. 1708-1711.
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Adams, RW, Aguilar, JA, Atkinson, KD, Cowley, MJ, Elliott, PIP, Duckett, SB, Green, GGR, Khazal, IG, Lopez-Serrano, J & Williamson, DC 2009, 'Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer', Science, vol. 323, no. 5922, pp. 1708-1711. https://doi.org/10.1126/science.1168877

Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. / Adams, Ralph W.; Aguilar, Juan A.; Atkinson, Kevin D.; Cowley, Michael J.; Elliott, Paul I P; Duckett, Simon B.; Green, Gary G R; Khazal, Iman G.; Lopez-Serrano, Joaquin; Williamson, David C.

In: Science, Vol. 323, No. 5922, 27.03.2009, p. 1708-1711.

Research output: Contribution to journalArticle

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AU - Adams, Ralph W.

AU - Aguilar, Juan A.

AU - Atkinson, Kevin D.

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AU - Elliott, Paul I P

AU - Duckett, Simon B.

AU - Green, Gary G R

AU - Khazal, Iman G.

AU - Lopez-Serrano, Joaquin

AU - Williamson, David C.

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Adams RW, Aguilar JA, Atkinson KD, Cowley MJ, Elliott PIP, Duckett SB et al. Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. Science. 2009 Mar 27;323(5922):1708-1711. https://doi.org/10.1126/science.1168877