Abstract
| Original language | English |
|---|---|
| Article number | 115541 |
| Number of pages | 8 |
| Journal | Carbohydrate Polymers |
| Volume | 229 |
| Early online date | 4 Nov 2019 |
| DOIs | |
| Publication status | E-pub ahead of print - 4 Nov 2019 |
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Rheo-dissolution : A new platform for the simultaneous measurement of rheology and drug release. / Senjoti, Faria; Ghori, Muhammad Usman ; Diryak, Ramadan; Conway, Barbara; Morris, Gordon; Smith, Alan.
In: Carbohydrate Polymers, Vol. 229, 115541, 01.02.2020.Research output: Contribution to journal › Article
TY - JOUR
T1 - Rheo-dissolution
T2 - A new platform for the simultaneous measurement of rheology and drug release
AU - Senjoti, Faria
AU - Ghori, Muhammad Usman
AU - Diryak, Ramadan
AU - Conway, Barbara
AU - Morris, Gordon
AU - Smith, Alan
PY - 2019/11/4
Y1 - 2019/11/4
N2 - There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.
AB - There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.
KW - Rheo-dissolution
KW - Gelation
KW - polysaccharides
KW - Drug delivery
KW - in situ gelation
KW - In situ
KW - Hydrogel
KW - Rheology
UR - http://www.scopus.com/inward/record.url?scp=85075382744&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.115541
DO - 10.1016/j.carbpol.2019.115541
M3 - Article
VL - 229
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
M1 - 115541
ER -