Rheo-dissolution

A new platform for the simultaneous measurement of rheology and drug release

Research output: Contribution to journalArticle

Abstract

There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.
Original languageEnglish
Article number115541
Number of pages8
JournalCarbohydrate Polymers
Early online date4 Nov 2019
DOIs
Publication statusE-pub ahead of print - 4 Nov 2019

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Rheology
Alginate
Dissolution
Timolol
Fluids
Pharmaceutical Preparations
Contacts (fluid mechanics)
Metronidazole
Gelation
Drug delivery
Gels
Liquids
alginic acid
gellan gum

Cite this

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title = "Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release",
abstract = "There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.",
keywords = "Rheo-dissolution, Gelation, polysaccharides, Drug delivery, in situ gelation, In situ, Hydrogel",
author = "Faria Senjoti and Ghori, {Muhammad Usman} and Ramadan Diryak and Barbara Conway and Gordon Morris and Alan Smith",
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AU - Ghori, Muhammad Usman

AU - Diryak, Ramadan

AU - Conway, Barbara

AU - Morris, Gordon

AU - Smith, Alan

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N2 - There is great potential to improve drug delivery through the use of in-situ gelling delivery systems. Here we demonstrate a technique capable of measuring changes in rheology (gelation and/or dissolution) of in-situ gelling delivery systems on contact with physiological fluid, while simultaneously analysing drug release. An ocular in-situ gelling formulation (gellan and timolol maleate) and an in-situ gelling oral liquid (alginate and metronidazole) were used as exemplar formulations. The method allowed profiling of increasing gellan concentration resulting in a reduction of timolol maleate released into simulated lacrimal fluid. When alginate was used as an in-situ gelling oral formulation there was a rapid increase in Gʹ on contact with simulated gastric fluid. When this was changed to simulated intestinal fluid, drug release rate increased rapidly, coinciding with alginate gel dissolution. This work highlights the potential of this technology as a tool in development and optimisation of these increasingly popular delivery systems.

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KW - Drug delivery

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KW - In situ

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