Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Zahra Almodares, Stephanie J. Lucas, Benjamin D. Crossley, Aida M. Basri, Christopher M. Pask, Andrew J. Hebden, Roger M. Phillips, Patrick C. McGowan

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Abstract

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalInorganic Chemistry
Volume53
Issue number2
Early online date7 Jan 2014
DOIs
Publication statusPublished - 21 Jan 2014
Externally publishedYes

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Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., ... McGowan, P. C. (2014). Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. Inorganic Chemistry, 53(2), 727-736. https://doi.org/10.1021/ic401529u