Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Zahra Almodares, Stephanie J. Lucas, Benjamin D. Crossley, Aida M. Basri, Christopher M. Pask, Andrew J. Hebden, Roger M. Phillips, Patrick C. McGowan

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalInorganic Chemistry
Volume53
Issue number2
Early online date7 Jan 2014
DOIs
Publication statusPublished - 21 Jan 2014
Externally publishedYes

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Iridium
Rhodium
Ruthenium
iridium
rhodium
Antineoplastic Agents
ruthenium
Cytotoxicity
cells
Cisplatin
halides
Ligands
ligands
picolinamide

Cite this

Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., ... McGowan, P. C. (2014). Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. Inorganic Chemistry, 53(2), 727-736. https://doi.org/10.1021/ic401529u
Almodares, Zahra ; Lucas, Stephanie J. ; Crossley, Benjamin D. ; Basri, Aida M. ; Pask, Christopher M. ; Hebden, Andrew J. ; Phillips, Roger M. ; McGowan, Patrick C. / Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. In: Inorganic Chemistry. 2014 ; Vol. 53, No. 2. pp. 727-736.
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Almodares, Z, Lucas, SJ, Crossley, BD, Basri, AM, Pask, CM, Hebden, AJ, Phillips, RM & McGowan, PC 2014, 'Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents', Inorganic Chemistry, vol. 53, no. 2, pp. 727-736. https://doi.org/10.1021/ic401529u

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. / Almodares, Zahra; Lucas, Stephanie J.; Crossley, Benjamin D.; Basri, Aida M.; Pask, Christopher M.; Hebden, Andrew J.; Phillips, Roger M.; McGowan, Patrick C.

In: Inorganic Chemistry, Vol. 53, No. 2, 21.01.2014, p. 727-736.

Research output: Contribution to journalArticle

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AU - Pask, Christopher M.

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AU - Phillips, Roger M.

AU - McGowan, Patrick C.

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