Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Zahra Almodares; Stephanie J. Lucas; Benjamin D. Crossley; Aida M. Basri; Christopher M. Pask; Andrew J. Hebden; Roger M. Phillips; Patrick C. McGowan

doi:10.1021/ic401529u

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Zahra Almodares, Stephanie J. Lucas, Benjamin D. Crossley, Aida M. Basri, Christopher M. Pask, Andrew J. Hebden, Roger M. Phillips, Patrick C. McGowan

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC₅₀ values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

Original language	English
Pages (from-to)	727-736
Number of pages	10
Journal	Inorganic Chemistry
Volume	53
Issue number	2
Early online date	7 Jan 2014
DOIs	https://doi.org/10.1021/ic401529u
Publication status	Published - 21 Jan 2014
Externally published	Yes

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title = "Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents",

abstract = "Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.",

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author = "Zahra Almodares and Lucas, {Stephanie J.} and Crossley, {Benjamin D.} and Basri, {Aida M.} and Pask, {Christopher M.} and Hebden, {Andrew J.} and Phillips, {Roger M.} and McGowan, {Patrick C.}",

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AU - Almodares, Zahra

AU - Lucas, Stephanie J.

AU - Crossley, Benjamin D.

AU - Basri, Aida M.

AU - Pask, Christopher M.

AU - Hebden, Andrew J.

AU - Phillips, Roger M.

AU - McGowan, Patrick C.

PY - 2014/1/21

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N2 - Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

AB - Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

KW - amide

KW - antineoplastic agent

KW - iridium

KW - organometallic compound

KW - picolinamide

KW - picolinic acid derivative

KW - rhodium

KW - ruthenium

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KW - chemistry

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KW - human

KW - IC 50

KW - MCF 7 cell line

KW - synthesis

KW - Amides

KW - Antineoplastic Agents

KW - Cell Hypoxia

KW - HT29 Cells

KW - Humans

KW - Inhibitory Concentration 50

KW - Iridium

KW - MCF-7 Cells

KW - Organometallic Compounds

KW - Picolinic Acids

KW - Rhodium

KW - Ruthenium

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JO - Inorganic Chemistry

JF - Inorganic Chemistry

SN - 0020-1669

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ER -

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

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Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

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