RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection

Samantha Griffiths, Neil Portman, Philip R. Taylor, Siamon Gordon, Michael L. Ginger, Keith Gull

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

LanguageEnglish
Pages1248-1250
Number of pages3
JournalEukaryotic Cell
Volume6
Issue number7
DOIs
Publication statusPublished - 1 Jul 2007
Externally publishedYes

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Cytokinesis
Trypanosomiasis
Flagella
RNA Interference
Cell Movement
Infection

Cite this

Griffiths, Samantha ; Portman, Neil ; Taylor, Philip R. ; Gordon, Siamon ; Ginger, Michael L. ; Gull, Keith. / RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection. In: Eukaryotic Cell. 2007 ; Vol. 6, No. 7. pp. 1248-1250.
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RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection. / Griffiths, Samantha; Portman, Neil; Taylor, Philip R.; Gordon, Siamon; Ginger, Michael L.; Gull, Keith.

In: Eukaryotic Cell, Vol. 6, No. 7, 01.07.2007, p. 1248-1250.

Research output: Contribution to journalArticle

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