Role of flame-retardants as EDCs in metabolic disorders

Talib Hussain, Abid Yousaf, Muhammad Usman Ghori, Ikram Ullah Khan , Tahir Ali Chohan, Syed Rizvi, Yasser Shahzad

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The destructive potential of fire is well known and thus it makes sense to prevent it from happening at all, or slow its rate of spread and to be able to stop it as soon as it happens in undesirable situations. Flame retardants (FRs), as the name indicates, are chemical substances with the capability of slowing down or preventing the growth of fire, have been used in many households and industrial products for a while now. Many kinds of FRs are currently in use, such as halogenated, organophosphosphate, nitrogenous, inorganic and intumescent coatings. These products are also well known to have many side effects, including carcinogenicity, reproductive toxicity, endocrine disruption, and immune system disorders. Not all fire retardants are made or function the same way thus vary in extent of fire-retardant capacity as well as toxic side effects. Herein we succinctly describe various classes of chemical FRs, and associated biological hazards to humans. We have also described underlying mechanisms or pathways that may possibly be involved in inducing endocrine disruption leading to obesity, diabetes, oxidative stress and inflammatory responses.
Original languageEnglish
Title of host publicationEndocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies
EditorsMuhammad Sajid Hamid Akash, Kanwal Rehman, Muhammad Zaffar Hashmi
PublisherSpringer Nature Switzerland AG
Number of pages18
ISBN (Electronic)9783030459239
ISBN (Print)9783030459222
Publication statusPublished - 5 Aug 2020

Publication series

NameEmerging Contaminants and Associated Treatment Technologies
ISSN (Print)2524-6402


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