TY - CHAP
T1 - Role of flame-retardants as EDCs in metabolic disorders
AU - Hussain, Talib
AU - Yousaf, Abid
AU - Ghori, Muhammad Usman
AU - Khan , Ikram Ullah
AU - Chohan, Tahir Ali
AU - Rizvi, Syed
AU - Shahzad, Yasser
PY - 2020/8/5
Y1 - 2020/8/5
N2 - The destructive potential of fire is well known and thus it makes sense to prevent it from happening at all, or slow its rate of spread and to be able to stop it as soon as it happens in undesirable situations. Flame retardants (FRs), as the name indicates, are chemical substances with the capability of slowing down or preventing the growth of fire, have been used in many households and industrial products for a while now. Many kinds of FRs are currently in use, such as halogenated, organophosphosphate, nitrogenous, inorganic and intumescent coatings. These products are also well known to have many side effects, including carcinogenicity, reproductive toxicity, endocrine disruption, and immune system disorders. Not all fire retardants are made or function the same way thus vary in extent of fire-retardant capacity as well as toxic side effects. Herein we succinctly describe various classes of chemical FRs, and associated biological hazards to humans. We have also described underlying mechanisms or pathways that may possibly be involved in inducing endocrine disruption leading to obesity, diabetes, oxidative stress and inflammatory responses.
AB - The destructive potential of fire is well known and thus it makes sense to prevent it from happening at all, or slow its rate of spread and to be able to stop it as soon as it happens in undesirable situations. Flame retardants (FRs), as the name indicates, are chemical substances with the capability of slowing down or preventing the growth of fire, have been used in many households and industrial products for a while now. Many kinds of FRs are currently in use, such as halogenated, organophosphosphate, nitrogenous, inorganic and intumescent coatings. These products are also well known to have many side effects, including carcinogenicity, reproductive toxicity, endocrine disruption, and immune system disorders. Not all fire retardants are made or function the same way thus vary in extent of fire-retardant capacity as well as toxic side effects. Herein we succinctly describe various classes of chemical FRs, and associated biological hazards to humans. We have also described underlying mechanisms or pathways that may possibly be involved in inducing endocrine disruption leading to obesity, diabetes, oxidative stress and inflammatory responses.
KW - Biological hazard
KW - brominated fire retardants
KW - oxidative stress
KW - obesity
KW - type 2 diabetes
UR - https://www.springer.com/gp/book/9783030459222
U2 - 10.1007/978-3-030-45923-9_14
DO - 10.1007/978-3-030-45923-9_14
M3 - Chapter
SN - 9783030459222
T3 - Emerging Contaminants and Associated Treatment Technologies
SP - 221
EP - 238
BT - Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies
A2 - Akash, Muhammad Sajid Hamid
A2 - Rehman, Kanwal
A2 - Hashmi, Muhammad Zaffar
PB - Springer Nature Switzerland AG
ER -