Scale-down of Heterogeneous Catalytic Reduction Using a Bubble Column: Controlled Mass Transfer down to 3 cm3 Working Volume

John H. Atherton, Ahmed Elmekawy, Alan Hall, Howard Williams

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Best practice for scale-down of gas-liquid reactions requires control of the volumetric mass transfer coefficient, kLa. It is demonstrated that the use of small bubble columns can provide well-controlled kLa and catalyst dispersion down to a scale of 3 cm3. This scale is several times less than has been previously demonstrated for heterogeneously catalysed reduction using gaseous hydrogen and is more easily reproduced than small scale stirred vessels. Measurements have been made at a fixed total gas flow, with the effective mass transfer rate being adjustable by dilution of the hydrogen flow with either helium or nitrogen.
Original languageEnglish
Pages (from-to)1159-1163
Number of pages5
JournalOrganic Process Research and Development
Volume19
Issue number9
DOIs
Publication statusPublished - 18 Sep 2015

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Bubble columns
mass transfer
Hydrogen
bubbles
Mass transfer
Helium
Dilution
Flow of gases
Nitrogen
Gases
reaction control
Catalysts
Liquids
hydrogen
gas flow
vessels
dilution
helium
nitrogen
catalysts

Cite this

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title = "Scale-down of Heterogeneous Catalytic Reduction Using a Bubble Column: Controlled Mass Transfer down to 3 cm3 Working Volume",
abstract = "Best practice for scale-down of gas-liquid reactions requires control of the volumetric mass transfer coefficient, kLa. It is demonstrated that the use of small bubble columns can provide well-controlled kLa and catalyst dispersion down to a scale of 3 cm3. This scale is several times less than has been previously demonstrated for heterogeneously catalysed reduction using gaseous hydrogen and is more easily reproduced than small scale stirred vessels. Measurements have been made at a fixed total gas flow, with the effective mass transfer rate being adjustable by dilution of the hydrogen flow with either helium or nitrogen.",
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Scale-down of Heterogeneous Catalytic Reduction Using a Bubble Column: Controlled Mass Transfer down to 3 cm3 Working Volume. / Atherton, John H.; Elmekawy, Ahmed; Hall, Alan; Williams, Howard.

In: Organic Process Research and Development, Vol. 19, No. 9, 18.09.2015, p. 1159-1163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Scale-down of Heterogeneous Catalytic Reduction Using a Bubble Column: Controlled Mass Transfer down to 3 cm3 Working Volume

AU - Atherton, John H.

AU - Elmekawy, Ahmed

AU - Hall, Alan

AU - Williams, Howard

PY - 2015/9/18

Y1 - 2015/9/18

N2 - Best practice for scale-down of gas-liquid reactions requires control of the volumetric mass transfer coefficient, kLa. It is demonstrated that the use of small bubble columns can provide well-controlled kLa and catalyst dispersion down to a scale of 3 cm3. This scale is several times less than has been previously demonstrated for heterogeneously catalysed reduction using gaseous hydrogen and is more easily reproduced than small scale stirred vessels. Measurements have been made at a fixed total gas flow, with the effective mass transfer rate being adjustable by dilution of the hydrogen flow with either helium or nitrogen.

AB - Best practice for scale-down of gas-liquid reactions requires control of the volumetric mass transfer coefficient, kLa. It is demonstrated that the use of small bubble columns can provide well-controlled kLa and catalyst dispersion down to a scale of 3 cm3. This scale is several times less than has been previously demonstrated for heterogeneously catalysed reduction using gaseous hydrogen and is more easily reproduced than small scale stirred vessels. Measurements have been made at a fixed total gas flow, with the effective mass transfer rate being adjustable by dilution of the hydrogen flow with either helium or nitrogen.

U2 - 10.1021/acs.oprd.5b00034

DO - 10.1021/acs.oprd.5b00034

M3 - Article

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JO - Organic Process Research and Development

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SN - 1083-6160

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