Selective Hydroboration–Oxidation of Terminal Alkenes under Flow Conditions

Mohamed Elsherbini, Florence Huynh, Alice Dunbabin, Rudolf K. Allemann, Thomas Wirth

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


An efficient flow process for the selective hydroboration and oxidation of different alkenes using 9-borabicyclo(3.3.1)nonane (9-BBN) allows facile conversion in high productivity (1.4 g h−1) of amorpha-4,11-diene to the corresponding alcohol, which is an advanced intermediate in the synthesis of the antimalarial drug artemisinin. The in situ reaction of borane and 1,5-cyclooctadiene using a simple flow generator proved to be a cost efficient solution for the generation of 9-BBN.

Original languageEnglish
Pages (from-to)11423-11425
Number of pages3
JournalChemistry - A European Journal
Issue number50
Early online date24 Apr 2020
Publication statusPublished - 4 Sep 2020
Externally publishedYes


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