Abstract
An efficient flow process for the selective hydroboration and oxidation of different alkenes using 9-borabicyclo(3.3.1)nonane (9-BBN) allows facile conversion in high productivity (1.4 g h−1) of amorpha-4,11-diene to the corresponding alcohol, which is an advanced intermediate in the synthesis of the antimalarial drug artemisinin. The in situ reaction of borane and 1,5-cyclooctadiene using a simple flow generator proved to be a cost efficient solution for the generation of 9-BBN.
Original language | English |
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Pages (from-to) | 11423-11425 |
Number of pages | 3 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 50 |
Early online date | 24 Apr 2020 |
DOIs | |
Publication status | Published - 4 Sep 2020 |
Externally published | Yes |