Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair

Karen H.L. Kwan, Kelvin W.K. Yeung, Xuelai Liu, Kenneth K.Y. Wong, Ho Cheung Shum, Yun Wah Lam, Shuk Han Cheng, Kenneth M.C. Cheung, Michael K.T. To

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


This study demonstrates a novel method of using silver nanoparticles for Achilles tendon injury healing. In vitro results indicated a stimulatory effect on cell proliferation and collagen synthesis with silver nanoparticles. Biomechanical test on the 42-day post operation Achilles tendon sample exhibited a significant improvement in tensile modulus when compared to the untreated group. Histology suggested that silver nanoparticles promoted cell alignment and proteoglycan synthesis. The collagen deposition was also improved. An alleviation of tumor necrosis factor α, and an increase in fibromodulin and proliferating cell nuclear antigen expression were seen in silver nanoparticles group by immunohistochemistry. This study further corroborates the finding of our previous study that silver nanoparticles help to restore the functionality of injured connective tissues. We believe that the anti-inflammatory nature of silver nanoparticles has an important role in accelerating the healing process and reducing scarring, leading to better functional outcome. 

Original languageEnglish
Pages (from-to)1375-1383
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number7
Early online date10 Dec 2013
Publication statusPublished - 1 Oct 2014
Externally publishedYes

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