Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention

Pratibha G Kakadia, Barbara Conway

Research output: Contribution to journalArticle

Abstract

Healthcare-associated infections (HAIs) are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs, however; permeation, penetration, and access to deeper skin layers are restricted due to the barrier function of the stratum corneum (SC). Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Hair follicles, surrounded by a close network of blood capillaries and dendritic cells, are an important target for delivery of antimicrobials and present a unique microbial nidus for endogenous infections in situations where the barrier is disrupted, such as after surgery, for example, triclosan, a broad-spectrum antimicrobial agent, was encapsulated into nanoparticles using glyceryl behenate and glyceryl palmitostearate (GP) solid lipids, and incorporating Transcutol P, a known permeation enhancer at different ratios. Optimised formulation was stable over 90 d and in vitro permeation studies using full thickness porcine ear skin showed that the lipid-based nanoparticles enhanced delivery of triclosan into the skin and could direct the agent towards hair follicles, indicating their potential as a carrier system for antiseptic dermal delivery.

LanguageEnglish
Pages695-704
Number of pages10
JournalJournal of Microencapsulation
Volume35
Issue number7-8
Early online date30 Jan 2019
DOIs
Publication statusPublished - 2019

Fingerprint

Triclosan
infectious diseases
Nanoparticles
Lipids
lipids
delivery
Skin
Permeation
nanoparticles
Infection
Hair Follicle
hair
Antimicrobial agents
Local Anti-Infective Agents
Anti-Infective Agents
antiseptics
routes
Surgery
Blood
cornea

Cite this

@article{9873878288ba4a4bad133893eca111b2,
title = "Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention",
abstract = "Healthcare-associated infections (HAIs) are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs, however; permeation, penetration, and access to deeper skin layers are restricted due to the barrier function of the stratum corneum (SC). Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Hair follicles, surrounded by a close network of blood capillaries and dendritic cells, are an important target for delivery of antimicrobials and present a unique microbial nidus for endogenous infections in situations where the barrier is disrupted, such as after surgery, for example, triclosan, a broad-spectrum antimicrobial agent, was encapsulated into nanoparticles using glyceryl behenate and glyceryl palmitostearate (GP) solid lipids, and incorporating Transcutol P, a known permeation enhancer at different ratios. Optimised formulation was stable over 90 d and in vitro permeation studies using full thickness porcine ear skin showed that the lipid-based nanoparticles enhanced delivery of triclosan into the skin and could direct the agent towards hair follicles, indicating their potential as a carrier system for antiseptic dermal delivery.",
keywords = "Solid lipid nanoparticle, Healthcare-associated infection, Topical delivery, Triclosan, Skin antisepsis, Follicular delivery, topical delivery, follicular delivery, skin antisepsis, triclosan, healthcare-associated infection",
author = "Kakadia, {Pratibha G} and Barbara Conway",
year = "2019",
doi = "10.1080/02652048.2019.1576796",
language = "English",
volume = "35",
pages = "695--704",
journal = "Journal of Microencapsulation",
issn = "0265-2048",
publisher = "Informa Healthcare",
number = "7-8",

}

Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention. / Kakadia, Pratibha G; Conway, Barbara.

In: Journal of Microencapsulation, Vol. 35, No. 7-8, 2019, p. 695-704.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention

AU - Kakadia, Pratibha G

AU - Conway, Barbara

PY - 2019

Y1 - 2019

N2 - Healthcare-associated infections (HAIs) are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs, however; permeation, penetration, and access to deeper skin layers are restricted due to the barrier function of the stratum corneum (SC). Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Hair follicles, surrounded by a close network of blood capillaries and dendritic cells, are an important target for delivery of antimicrobials and present a unique microbial nidus for endogenous infections in situations where the barrier is disrupted, such as after surgery, for example, triclosan, a broad-spectrum antimicrobial agent, was encapsulated into nanoparticles using glyceryl behenate and glyceryl palmitostearate (GP) solid lipids, and incorporating Transcutol P, a known permeation enhancer at different ratios. Optimised formulation was stable over 90 d and in vitro permeation studies using full thickness porcine ear skin showed that the lipid-based nanoparticles enhanced delivery of triclosan into the skin and could direct the agent towards hair follicles, indicating their potential as a carrier system for antiseptic dermal delivery.

AB - Healthcare-associated infections (HAIs) are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs, however; permeation, penetration, and access to deeper skin layers are restricted due to the barrier function of the stratum corneum (SC). Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Hair follicles, surrounded by a close network of blood capillaries and dendritic cells, are an important target for delivery of antimicrobials and present a unique microbial nidus for endogenous infections in situations where the barrier is disrupted, such as after surgery, for example, triclosan, a broad-spectrum antimicrobial agent, was encapsulated into nanoparticles using glyceryl behenate and glyceryl palmitostearate (GP) solid lipids, and incorporating Transcutol P, a known permeation enhancer at different ratios. Optimised formulation was stable over 90 d and in vitro permeation studies using full thickness porcine ear skin showed that the lipid-based nanoparticles enhanced delivery of triclosan into the skin and could direct the agent towards hair follicles, indicating their potential as a carrier system for antiseptic dermal delivery.

KW - Solid lipid nanoparticle

KW - Healthcare-associated infection

KW - Topical delivery

KW - Triclosan

KW - Skin antisepsis

KW - Follicular delivery

KW - topical delivery

KW - follicular delivery

KW - skin antisepsis

KW - triclosan

KW - healthcare-associated infection

UR - http://www.scopus.com/inward/record.url?scp=85063106546&partnerID=8YFLogxK

U2 - 10.1080/02652048.2019.1576796

DO - 10.1080/02652048.2019.1576796

M3 - Article

VL - 35

SP - 695

EP - 704

JO - Journal of Microencapsulation

T2 - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 7-8

ER -