Solid state and dissolution behaviour of a low melting point drug in co-milled mixtures of Sesamum radiatum gum

S. Shaboun, Elijah Nep, Ndidi Ngwuluka, Adeola Adebisi, Barbara Conway, Alan Smith, Kofi Asare-Addo

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Abstract

The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.
Original languageEnglish
Number of pages9
JournalBritish Journal of Pharmacy
Volume3
Issue number1
DOIs
Publication statusPublished - 17 Dec 2018

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Sesamum
Ibuprofen
Gingiva
Freezing
Pharmaceutical Preparations
Gels
Research Personnel
Costs and Cost Analysis

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title = "Solid state and dissolution behaviour of a low melting point drug in co-milled mixtures of Sesamum radiatum gum",
abstract = "The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.",
keywords = "sesamum radiatum gum, solid dispersions, co-milling ibuprofen",
author = "S. Shaboun and Elijah Nep and Ndidi Ngwuluka and Adeola Adebisi and Barbara Conway and Alan Smith and Kofi Asare-Addo",
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T1 - Solid state and dissolution behaviour of a low melting point drug in co-milled mixtures of Sesamum radiatum gum

AU - Shaboun, S.

AU - Nep, Elijah

AU - Ngwuluka, Ndidi

AU - Adebisi, Adeola

AU - Conway, Barbara

AU - Smith, Alan

AU - Asare-Addo, Kofi

PY - 2018/12/17

Y1 - 2018/12/17

N2 - The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.

AB - The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.

KW - sesamum radiatum gum

KW - solid dispersions

KW - co-milling ibuprofen

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DO - 10.5920/bjpharm.2018.07

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