TY - JOUR
T1 - Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure
T2 - A systematic review
AU - Khatib, Mahalaqua Nazli
AU - Gode, Dilip
AU - Simkhada, Padam
AU - Agho, Kingsley
AU - Gaidhane, Shilpa
AU - Saxena, Deepak
AU - Unnikrishnan, B.
AU - Raut, Yogesh
AU - Kawalkar, Umesh
AU - Gaidhane, Abhay
AU - Zahiruddin, Quazi Syed
PY - 2014
Y1 - 2014
N2 - Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.
AB - Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.
KW - doxorubicin
KW - Ghrelin
KW - growth hormone secretagogue receptor
KW - heart failure
KW - isoprenaline
UR - http://www.scopus.com/inward/record.url?scp=84915767572&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:84915767572
VL - 7
SP - 30
EP - 42
JO - Annals of Tropical Medicine and Public Health
JF - Annals of Tropical Medicine and Public Health
SN - 1755-6783
IS - 1
ER -
