Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure: A systematic review

Mahalaqua Nazli Khatib, Dilip Gode, Padam Simkhada, Kingsley Agho, Shilpa Gaidhane, Deepak Saxena, B. Unnikrishnan, Yogesh Raut, Umesh Kawalkar, Abhay Gaidhane, Quazi Syed Zahiruddin

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.

Original languageEnglish
Pages (from-to)30-42
Number of pages13
JournalAnnals of Tropical Medicine and Public Health
Issue number1
Early online date20 Nov 2014
Publication statusPublished - 2014
Externally publishedYes


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