Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure: A systematic review

Mahalaqua Nazli Khatib, Dilip Gode, Padam Simkhada, Kingsley Agho, Shilpa Gaidhane, Deepak Saxena, B. Unnikrishnan, Yogesh Raut, Umesh Kawalkar, Abhay Gaidhane, Quazi Syed Zahiruddin

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.

Original languageEnglish
Pages (from-to)30-42
Number of pages13
JournalAnnals of Tropical Medicine and Public Health
Volume7
Issue number1
Early online date20 Nov 2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Ghrelin
Theoretical Models
Heart Failure
Ghrelin Receptor
Appetite Regulation
Sympathetic Nervous System
Autophagy
Appetite
Cardiovascular System
Reperfusion Injury
Weight Gain
Publications
Meta-Analysis
Anti-Inflammatory Agents
Animal Models
Body Weight
Ligands
Mortality

Cite this

Khatib, Mahalaqua Nazli ; Gode, Dilip ; Simkhada, Padam ; Agho, Kingsley ; Gaidhane, Shilpa ; Saxena, Deepak ; Unnikrishnan, B. ; Raut, Yogesh ; Kawalkar, Umesh ; Gaidhane, Abhay ; Zahiruddin, Quazi Syed. / Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure : A systematic review. In: Annals of Tropical Medicine and Public Health. 2014 ; Vol. 7, No. 1. pp. 30-42.
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abstract = "Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.",
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Khatib, MN, Gode, D, Simkhada, P, Agho, K, Gaidhane, S, Saxena, D, Unnikrishnan, B, Raut, Y, Kawalkar, U, Gaidhane, A & Zahiruddin, QS 2014, 'Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure: A systematic review', Annals of Tropical Medicine and Public Health, vol. 7, no. 1, pp. 30-42. https://doi.org/10.4103/1755-6783.145008

Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure : A systematic review. / Khatib, Mahalaqua Nazli; Gode, Dilip; Simkhada, Padam; Agho, Kingsley; Gaidhane, Shilpa; Saxena, Deepak; Unnikrishnan, B.; Raut, Yogesh; Kawalkar, Umesh; Gaidhane, Abhay; Zahiruddin, Quazi Syed.

In: Annals of Tropical Medicine and Public Health, Vol. 7, No. 1, 2014, p. 30-42.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure

T2 - A systematic review

AU - Khatib, Mahalaqua Nazli

AU - Gode, Dilip

AU - Simkhada, Padam

AU - Agho, Kingsley

AU - Gaidhane, Shilpa

AU - Saxena, Deepak

AU - Unnikrishnan, B.

AU - Raut, Yogesh

AU - Kawalkar, Umesh

AU - Gaidhane, Abhay

AU - Zahiruddin, Quazi Syed

PY - 2014

Y1 - 2014

N2 - Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.

AB - Background: Ghrelin was initially recognized as an endogenous ligand of growth hormone secretagogue receptor and was implicated in the regulation of food intake, and promoting weight gain. Ghrelin has been shown to improve cardiac function in patients suffering from heart failure (HF) though various mechanisms. The aim of the review is to summarize the main findings in this field, with the purpose of promoting further studies on the role of ghrelin on the cardiovascular system. Materials and Methods: All publications describing trials, systematic reviews, meta-analyses and review papers published within 1999-2014 of ghrelin in animal models of HF were sought through electronic and manual searches. Results: The literature searches identified 126 references and ten trials meeting the inclusion criteria were included in this review. All studies were carried out on male rats and experimental model of HF. Ghrelin has been shown to reduce mortality, increase appetite and body weight, and was found to improve the cardiac function parameters. Review found deficient information about adverse effects of ghrelin. Ghrelin exerts cardioprotective effects through modulation of sympathetic nervous system, inhibiting autophagy, antiinflammatory effects and protection against ischemia/reperfusion injury. Conclusion: Ghrelin seems to have a beneficial effect in rat models of HF and can offer an effective therapeutic target for improving outcome in HF.

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KW - Ghrelin

KW - growth hormone secretagogue receptor

KW - heart failure

KW - isoprenaline

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DO - 10.4103/1755-6783.145008

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