Some pharmacological studies on Morinda lucida

S. O. Awe, O. A. Olajide, J. O. Adeboye, J. M. Makinde

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: The methanol extract (MLE) and fractions (MLFX2 and MLFX5) isolated from Morinda lucida were studied for some pharmacological properties in animal models. Methods: Carrageenan-induced rat paw oedema model was used to test anti-inflammatory activity; the acetic acid-induced writhings and tail immersion test were used to evaluate analgesic effect; while antipyretic activity was evaluated by inducing pyrexia with lipopolysaccharide, and measuring the rectal temperature. The effect of MLE on phenobarbitone sleeping time was also tested. Results: MLE (6.25-50 mg/kg), and MLFX2 and MLFX5 (5 and 10 mg/kg) produced inhibition of the carrageenan-induced rat paw oedema. MLE (50-200 mg/kg) significantly reduced the number of writhings induced by acetic acid and elevated pain threshold in hot water test. MLFX5 significantly (P<0.05) reduced lipopolysaccharide-induced hyperpyrexia in rats while MLFX2 exhibited no such effects. MLE was also found to potentiate phenobarbitone induced sleeping time. Conclusion: MLE, MLFX2 and MLFX5 exhibited anti-inflammatory activity; MLE also showed analgesic, antipyretic effects and potentiated phenobarbitone sleeping time. However, MLFX2 showed analgesic activity in the acetic acid test while MLFX5 exihibited antipyretic effect.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalIndian Journal of Pharmacology
Volume30
Issue number1
Publication statusPublished - 1 Feb 1998
Externally publishedYes

Fingerprint

Morinda
Methanol
Pharmacology
Antipyretics
Phenobarbital
Acetic Acid
Analgesics
Carrageenan
Lipopolysaccharides
Edema
Anti-Inflammatory Agents
Pain Threshold
Immersion
Tail
Fever
Animal Models
Temperature
Water

Cite this

Awe, S. O., Olajide, O. A., Adeboye, J. O., & Makinde, J. M. (1998). Some pharmacological studies on Morinda lucida. Indian Journal of Pharmacology, 30(1), 38-42.
Awe, S. O. ; Olajide, O. A. ; Adeboye, J. O. ; Makinde, J. M. / Some pharmacological studies on Morinda lucida. In: Indian Journal of Pharmacology. 1998 ; Vol. 30, No. 1. pp. 38-42.
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Awe, SO, Olajide, OA, Adeboye, JO & Makinde, JM 1998, 'Some pharmacological studies on Morinda lucida', Indian Journal of Pharmacology, vol. 30, no. 1, pp. 38-42.

Some pharmacological studies on Morinda lucida. / Awe, S. O.; Olajide, O. A.; Adeboye, J. O.; Makinde, J. M.

In: Indian Journal of Pharmacology, Vol. 30, No. 1, 01.02.1998, p. 38-42.

Research output: Contribution to journalArticle

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AB - Objective: The methanol extract (MLE) and fractions (MLFX2 and MLFX5) isolated from Morinda lucida were studied for some pharmacological properties in animal models. Methods: Carrageenan-induced rat paw oedema model was used to test anti-inflammatory activity; the acetic acid-induced writhings and tail immersion test were used to evaluate analgesic effect; while antipyretic activity was evaluated by inducing pyrexia with lipopolysaccharide, and measuring the rectal temperature. The effect of MLE on phenobarbitone sleeping time was also tested. Results: MLE (6.25-50 mg/kg), and MLFX2 and MLFX5 (5 and 10 mg/kg) produced inhibition of the carrageenan-induced rat paw oedema. MLE (50-200 mg/kg) significantly reduced the number of writhings induced by acetic acid and elevated pain threshold in hot water test. MLFX5 significantly (P<0.05) reduced lipopolysaccharide-induced hyperpyrexia in rats while MLFX2 exhibited no such effects. MLE was also found to potentiate phenobarbitone induced sleeping time. Conclusion: MLE, MLFX2 and MLFX5 exhibited anti-inflammatory activity; MLE also showed analgesic, antipyretic effects and potentiated phenobarbitone sleeping time. However, MLFX2 showed analgesic activity in the acetic acid test while MLFX5 exihibited antipyretic effect.

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Awe SO, Olajide OA, Adeboye JO, Makinde JM. Some pharmacological studies on Morinda lucida. Indian Journal of Pharmacology. 1998 Feb 1;30(1):38-42.