Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS

Sean Ward, Michael I. Page, Patrick McHugh, Nicholas T. Powles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The project aim was to identify differences in the metabolomic profiles in the serum of patients with multiple sclerosis (MS), those with neuropathic pain (NP) and those with both MS and NP compared with controls and to identify potential biomarkers of each disease state. Metabolomic profiling was performed using ultra-high-performance liquid chromatography coupled to mass spectrometry and the data analysis involved parametric methods, principal component analysis, and discriminating filter analysis to determine the differences between disease and control serum samples. Sphingosine and dihydrosphingosine were identified as significant biomarkers.

Original languageEnglish
Pages (from-to)5929-5934
Number of pages6
JournalAnalytical Methods
Volume9
Issue number41
DOIs
Publication statusPublished - 25 Sep 2017

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Sphingosines
Sphingosine
Biomarkers
High performance liquid chromatography
Principal component analysis
Mass spectrometry
Metabolomics
safingol

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Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS. / Ward, Sean; Page, Michael I.; McHugh, Patrick; Powles, Nicholas T.

In: Analytical Methods, Vol. 9, No. 41, 25.09.2017, p. 5929-5934.

Research output: Contribution to journalArticle

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