Spironolactone for the Treatment of Moderate to Severe Acne in Adult Women: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow; Dinesh Sangarran Ramachandram; Syed Shahzad Hasan; Kaeshaelya Thiruchelvam

doi:10.1111/ajd.14428

Spironolactone for the Treatment of Moderate to Severe Acne in Adult Women: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam

Research output: Contribution to journal › Review article › peer-review

Abstract

This systematic review and meta-analysis aimed to assess the efficacy and safety of spironolactone for moderate to severe acne in adult women by synthesising data from randomised controlled trials (RCTs). The meta-analysis demonstrated that spironolactone significantly increased the odds of treatment success, with a pooled odds ratio (OR) of 2.51 compared to placebo or doxycycline. This analysis supports spironolactone as a highly effective treatment for moderate to severe acne in adult women, particularly in hormonally driven cases. Its efficacy, combined with its role as an alternative to long-term antibiotic therapy, makes it a valuable option for acne management in women population.

Original language	English
Number of pages	4
Journal	Australasian Journal of Dermatology
Early online date	6 Feb 2025
DOIs	https://doi.org/10.1111/ajd.14428
Publication status	E-pub ahead of print - 6 Feb 2025

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abstract = "This systematic review and meta-analysis aimed to assess the efficacy and safety of spironolactone for moderate to severe acne in adult women by synthesising data from randomised controlled trials (RCTs). The meta-analysis demonstrated that spironolactone significantly increased the odds of treatment success, with a pooled odds ratio (OR) of 2.51 compared to placebo or doxycycline. This analysis supports spironolactone as a highly effective treatment for moderate to severe acne in adult women, particularly in hormonally driven cases. Its efficacy, combined with its role as an alternative to long-term antibiotic therapy, makes it a valuable option for acne management in women population.",

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AU - Hasan, Syed Shahzad

AU - Thiruchelvam, Kaeshaelya

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AB - This systematic review and meta-analysis aimed to assess the efficacy and safety of spironolactone for moderate to severe acne in adult women by synthesising data from randomised controlled trials (RCTs). The meta-analysis demonstrated that spironolactone significantly increased the odds of treatment success, with a pooled odds ratio (OR) of 2.51 compared to placebo or doxycycline. This analysis supports spironolactone as a highly effective treatment for moderate to severe acne in adult women, particularly in hormonally driven cases. Its efficacy, combined with its role as an alternative to long-term antibiotic therapy, makes it a valuable option for acne management in women population.

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Spironolactone for the Treatment of Moderate to Severe Acne in Adult Women: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

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