Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris

A randomized, double-blind, prospective trial

Hamid Reza Kelidari, Majid Saeedi, Zohreh Hajheydari, Jafar Akbari, Katayoun Morteza-Semnani, Javad Akhtari, Hadi Valizadeh, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Spironolactone (SP) known as an anti-androgen drug, has been proven to be effective in treatment of acne. The quest to minimize the unnecessary systemic side effects associated with the oral drug administration of spironolactone, has led to a growing interest of loading SP on lipid nanoparticles to deliver the drug in a topical formulation. The aim of the current investigation was to prepare and compare the performance of SP loaded nanostructured lipid carrier (SP-NLC) and SP alcoholic gels (SP-ALC) on two groups of respective patient populations, group A and group B in the treatment of mild to moderate acne vulgaris. The results showed that SP-NLCs were spherical in shape with an average diameter of ~240 nm. The polydispersity index (PI) and zeta potential of these nanoparticles were 0.286 and -21.4 respectively. The gels showed non-Newtonian independent pseudoplastic and shear thinning behavior. The SP-NLCs was not toxic to fibroblast cell strains at the 24 and 48 h periods. Results showed that the mean number of total lesions (37.66 ± 9.27) and non-inflammatory lesions (29.26 ± 7.99) in group A significantly decreased to 20.31 ± 6.58 (p < 0.05) and to 13.95 ± 5.22 (p < 0.05) respectively. A similar pattern was observed for group B where the mean number of total lesions and non-inflammatory lesions reduced from 33.73 ± 9.40 to 19.13 ± 5.53 (p < 0.05) and from 25.65 ± 8.12 to 13.45 ± 4.48 (p < 0.05) respectively. The total lesion count (TLC) was significantly decreased from 37.16 ± 9.28 to 19.63 ± 6.36 (for group A; p < 0.071) and 32.60 ± 9.32 to 18.33 ± 5.55 (for group B; p < 0.05) respectively. After treatment with SP-NLC for 8 weeks, the water content of the skin significantly (p < 0.05) increased from 37.44 ± 8.85 to 45.69 ± 19.34 instrumental units. Therefore, the SP-NLC gel may help in controlling acne vulgaris with skin care benefits.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume146
Early online date18 May 2016
DOIs
Publication statusPublished - 1 Oct 2016

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Spironolactone
Acne Vulgaris
Lipids
lipids
Gels
gels
lesions
Skin
Nanoparticles
Shear thinning
Polydispersity
Zeta potential
Fibroblasts
drugs
Water content
Therapeutics
Cells
nanoparticles
shear thinning
Pharmaceutical Preparations

Cite this

Kelidari, Hamid Reza ; Saeedi, Majid ; Hajheydari, Zohreh ; Akbari, Jafar ; Morteza-Semnani, Katayoun ; Akhtari, Javad ; Valizadeh, Hadi ; Asare-Addo, Kofi ; Nokhodchi, Ali. / Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris : A randomized, double-blind, prospective trial. In: Colloids and Surfaces B: Biointerfaces. 2016 ; Vol. 146. pp. 47-53.
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Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris : A randomized, double-blind, prospective trial. / Kelidari, Hamid Reza; Saeedi, Majid; Hajheydari, Zohreh; Akbari, Jafar; Morteza-Semnani, Katayoun; Akhtari, Javad; Valizadeh, Hadi; Asare-Addo, Kofi; Nokhodchi, Ali.

In: Colloids and Surfaces B: Biointerfaces, Vol. 146, 01.10.2016, p. 47-53.

Research output: Contribution to journalArticle

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T1 - Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris

T2 - A randomized, double-blind, prospective trial

AU - Kelidari, Hamid Reza

AU - Saeedi, Majid

AU - Hajheydari, Zohreh

AU - Akbari, Jafar

AU - Morteza-Semnani, Katayoun

AU - Akhtari, Javad

AU - Valizadeh, Hadi

AU - Asare-Addo, Kofi

AU - Nokhodchi, Ali

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Spironolactone (SP) known as an anti-androgen drug, has been proven to be effective in treatment of acne. The quest to minimize the unnecessary systemic side effects associated with the oral drug administration of spironolactone, has led to a growing interest of loading SP on lipid nanoparticles to deliver the drug in a topical formulation. The aim of the current investigation was to prepare and compare the performance of SP loaded nanostructured lipid carrier (SP-NLC) and SP alcoholic gels (SP-ALC) on two groups of respective patient populations, group A and group B in the treatment of mild to moderate acne vulgaris. The results showed that SP-NLCs were spherical in shape with an average diameter of ~240 nm. The polydispersity index (PI) and zeta potential of these nanoparticles were 0.286 and -21.4 respectively. The gels showed non-Newtonian independent pseudoplastic and shear thinning behavior. The SP-NLCs was not toxic to fibroblast cell strains at the 24 and 48 h periods. Results showed that the mean number of total lesions (37.66 ± 9.27) and non-inflammatory lesions (29.26 ± 7.99) in group A significantly decreased to 20.31 ± 6.58 (p < 0.05) and to 13.95 ± 5.22 (p < 0.05) respectively. A similar pattern was observed for group B where the mean number of total lesions and non-inflammatory lesions reduced from 33.73 ± 9.40 to 19.13 ± 5.53 (p < 0.05) and from 25.65 ± 8.12 to 13.45 ± 4.48 (p < 0.05) respectively. The total lesion count (TLC) was significantly decreased from 37.16 ± 9.28 to 19.63 ± 6.36 (for group A; p < 0.071) and 32.60 ± 9.32 to 18.33 ± 5.55 (for group B; p < 0.05) respectively. After treatment with SP-NLC for 8 weeks, the water content of the skin significantly (p < 0.05) increased from 37.44 ± 8.85 to 45.69 ± 19.34 instrumental units. Therefore, the SP-NLC gel may help in controlling acne vulgaris with skin care benefits.

AB - Spironolactone (SP) known as an anti-androgen drug, has been proven to be effective in treatment of acne. The quest to minimize the unnecessary systemic side effects associated with the oral drug administration of spironolactone, has led to a growing interest of loading SP on lipid nanoparticles to deliver the drug in a topical formulation. The aim of the current investigation was to prepare and compare the performance of SP loaded nanostructured lipid carrier (SP-NLC) and SP alcoholic gels (SP-ALC) on two groups of respective patient populations, group A and group B in the treatment of mild to moderate acne vulgaris. The results showed that SP-NLCs were spherical in shape with an average diameter of ~240 nm. The polydispersity index (PI) and zeta potential of these nanoparticles were 0.286 and -21.4 respectively. The gels showed non-Newtonian independent pseudoplastic and shear thinning behavior. The SP-NLCs was not toxic to fibroblast cell strains at the 24 and 48 h periods. Results showed that the mean number of total lesions (37.66 ± 9.27) and non-inflammatory lesions (29.26 ± 7.99) in group A significantly decreased to 20.31 ± 6.58 (p < 0.05) and to 13.95 ± 5.22 (p < 0.05) respectively. A similar pattern was observed for group B where the mean number of total lesions and non-inflammatory lesions reduced from 33.73 ± 9.40 to 19.13 ± 5.53 (p < 0.05) and from 25.65 ± 8.12 to 13.45 ± 4.48 (p < 0.05) respectively. The total lesion count (TLC) was significantly decreased from 37.16 ± 9.28 to 19.63 ± 6.36 (for group A; p < 0.071) and 32.60 ± 9.32 to 18.33 ± 5.55 (for group B; p < 0.05) respectively. After treatment with SP-NLC for 8 weeks, the water content of the skin significantly (p < 0.05) increased from 37.44 ± 8.85 to 45.69 ± 19.34 instrumental units. Therefore, the SP-NLC gel may help in controlling acne vulgaris with skin care benefits.

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KW - Nanostructured lipid carriers (NLCs)

KW - Skin condition

KW - Spironolactone

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