Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women

Emma Harris, Mark Rakobowchuk, Karen M. Birch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: The improvement of vascular health in the exercising limb can be attained by sprint interval training (SIT). However, the effects on systemic vascular function and on circulating angiogenic cells (CACs) which may contribute to endothelial repair have not been investigated. Additionally, a comparison between SIT and sprint continuous training (SCT) which is less time committing has not been made. Methods: 12 women (22±2 yrs) completed 12 sessions of either SIT (n = 6) or work-matched SCT (n = 6) on 3 days/week. Pre and post-Training assessments included brachial artery endothelial function and peripheral blood analysis for CAC number (CD34+/CD34+CD45dim). CAC function was measured by migration and adhesion assays. Cardio-respiratory fitness, carotid arterial stiffness and carotid-radial and brachial-foot pulse wave velocity (PWV) were also evaluated. Results: CD34+ CACs increased following training in both groups but CD34+CD45dimdid not (Pre CD34+: 40±21/105 leukocytes, Post CD34+: 56±24/105 leukocytes, main time effect p,0.05). Brachial artery flow-mediated dilation (FMD) increased following SIT but SCT had no effect (Pre SIT: 5.0±3.4%, Post SIT: 5.9±3.0%, Pre SCT: 7.2±2.7%, Post SCT: 6.5±2.9%; group x time interaction p = 0.08). VVO2max increased in both training groups (Pre: 34.6±4.6 mlNkgNml21, Post: 36.9±5.4 mlNkgNml21, main time effect p,0.05). CAC function, carotid arterial stiffness and PWV did not change after training (p.0.05). Discussion: SCT involving little time commitment is comparable to SIT in increasing CD34+ cell number and VVO2max. An increased mobilisation of CD34+ CACs suggests that sprint training may be an effective method to enhance vascular repair.

Original languageEnglish
Article numbere108720
Number of pages11
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - 29 Sep 2014
Externally publishedYes

Fingerprint

blood vessels
Repair
Blood Vessels
Stiffness
cells
Pulse Wave Analysis
Vascular Stiffness
Brachial Artery
arteries
leukocytes
Leukocytes
Cell Count
Assays
Blood
Adhesion
Health
hematologic tests
High-Intensity Interval Training
limbs (animal)
adhesion

Cite this

@article{257ceaa8b2454520952ac8b6f59333b9,
title = "Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women",
abstract = "Introduction: The improvement of vascular health in the exercising limb can be attained by sprint interval training (SIT). However, the effects on systemic vascular function and on circulating angiogenic cells (CACs) which may contribute to endothelial repair have not been investigated. Additionally, a comparison between SIT and sprint continuous training (SCT) which is less time committing has not been made. Methods: 12 women (22±2 yrs) completed 12 sessions of either SIT (n = 6) or work-matched SCT (n = 6) on 3 days/week. Pre and post-Training assessments included brachial artery endothelial function and peripheral blood analysis for CAC number (CD34+/CD34+CD45dim). CAC function was measured by migration and adhesion assays. Cardio-respiratory fitness, carotid arterial stiffness and carotid-radial and brachial-foot pulse wave velocity (PWV) were also evaluated. Results: CD34+ CACs increased following training in both groups but CD34+CD45dimdid not (Pre CD34+: 40±21/105 leukocytes, Post CD34+: 56±24/105 leukocytes, main time effect p,0.05). Brachial artery flow-mediated dilation (FMD) increased following SIT but SCT had no effect (Pre SIT: 5.0±3.4{\%}, Post SIT: 5.9±3.0{\%}, Pre SCT: 7.2±2.7{\%}, Post SCT: 6.5±2.9{\%}; group x time interaction p = 0.08). VVO2max increased in both training groups (Pre: 34.6±4.6 mlNkgNml21, Post: 36.9±5.4 mlNkgNml21, main time effect p,0.05). CAC function, carotid arterial stiffness and PWV did not change after training (p.0.05). Discussion: SCT involving little time commitment is comparable to SIT in increasing CD34+ cell number and VVO2max. An increased mobilisation of CD34+ CACs suggests that sprint training may be an effective method to enhance vascular repair.",
author = "Emma Harris and Mark Rakobowchuk and Birch, {Karen M.}",
year = "2014",
month = "9",
day = "29",
doi = "10.1371/journal.pone.0108720",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women. / Harris, Emma; Rakobowchuk, Mark; Birch, Karen M.

In: PLoS One, Vol. 9, No. 9, e108720, 29.09.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women

AU - Harris, Emma

AU - Rakobowchuk, Mark

AU - Birch, Karen M.

PY - 2014/9/29

Y1 - 2014/9/29

N2 - Introduction: The improvement of vascular health in the exercising limb can be attained by sprint interval training (SIT). However, the effects on systemic vascular function and on circulating angiogenic cells (CACs) which may contribute to endothelial repair have not been investigated. Additionally, a comparison between SIT and sprint continuous training (SCT) which is less time committing has not been made. Methods: 12 women (22±2 yrs) completed 12 sessions of either SIT (n = 6) or work-matched SCT (n = 6) on 3 days/week. Pre and post-Training assessments included brachial artery endothelial function and peripheral blood analysis for CAC number (CD34+/CD34+CD45dim). CAC function was measured by migration and adhesion assays. Cardio-respiratory fitness, carotid arterial stiffness and carotid-radial and brachial-foot pulse wave velocity (PWV) were also evaluated. Results: CD34+ CACs increased following training in both groups but CD34+CD45dimdid not (Pre CD34+: 40±21/105 leukocytes, Post CD34+: 56±24/105 leukocytes, main time effect p,0.05). Brachial artery flow-mediated dilation (FMD) increased following SIT but SCT had no effect (Pre SIT: 5.0±3.4%, Post SIT: 5.9±3.0%, Pre SCT: 7.2±2.7%, Post SCT: 6.5±2.9%; group x time interaction p = 0.08). VVO2max increased in both training groups (Pre: 34.6±4.6 mlNkgNml21, Post: 36.9±5.4 mlNkgNml21, main time effect p,0.05). CAC function, carotid arterial stiffness and PWV did not change after training (p.0.05). Discussion: SCT involving little time commitment is comparable to SIT in increasing CD34+ cell number and VVO2max. An increased mobilisation of CD34+ CACs suggests that sprint training may be an effective method to enhance vascular repair.

AB - Introduction: The improvement of vascular health in the exercising limb can be attained by sprint interval training (SIT). However, the effects on systemic vascular function and on circulating angiogenic cells (CACs) which may contribute to endothelial repair have not been investigated. Additionally, a comparison between SIT and sprint continuous training (SCT) which is less time committing has not been made. Methods: 12 women (22±2 yrs) completed 12 sessions of either SIT (n = 6) or work-matched SCT (n = 6) on 3 days/week. Pre and post-Training assessments included brachial artery endothelial function and peripheral blood analysis for CAC number (CD34+/CD34+CD45dim). CAC function was measured by migration and adhesion assays. Cardio-respiratory fitness, carotid arterial stiffness and carotid-radial and brachial-foot pulse wave velocity (PWV) were also evaluated. Results: CD34+ CACs increased following training in both groups but CD34+CD45dimdid not (Pre CD34+: 40±21/105 leukocytes, Post CD34+: 56±24/105 leukocytes, main time effect p,0.05). Brachial artery flow-mediated dilation (FMD) increased following SIT but SCT had no effect (Pre SIT: 5.0±3.4%, Post SIT: 5.9±3.0%, Pre SCT: 7.2±2.7%, Post SCT: 6.5±2.9%; group x time interaction p = 0.08). VVO2max increased in both training groups (Pre: 34.6±4.6 mlNkgNml21, Post: 36.9±5.4 mlNkgNml21, main time effect p,0.05). CAC function, carotid arterial stiffness and PWV did not change after training (p.0.05). Discussion: SCT involving little time commitment is comparable to SIT in increasing CD34+ cell number and VVO2max. An increased mobilisation of CD34+ CACs suggests that sprint training may be an effective method to enhance vascular repair.

UR - http://www.scopus.com/inward/record.url?scp=84942475355&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0108720

DO - 10.1371/journal.pone.0108720

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 9

M1 - e108720

ER -