Stem cells: The therapeutic role in the treatment of diabetes mellitus

Gary G. Adams, Lee Buttery, Snow Stolnik, Gordon Morris, Stephen Harding, Nan Wang

Research output: Contribution to journalArticle

Abstract

The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus. 

These findings substantiate our method of encapsulation as opposed to the traditional formation strategies, for example those described by Cameron et al, where embryoid body formation is required (Hu 2003; Cameron 2006). These systems are probably used because they are known to generate three germ layers characteristic of embryo development, but EB formation is not an essential requirement in the production of insulin.

LanguageEnglish
Pages285-304
Number of pages20
JournalBiotechnology and Genetic Engineering Reviews
Volume27
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Medical problems
Stem cells
Diabetes Mellitus
Stem Cells
Cells
Embryoid Bodies
Cell Line
Germ Layers
Mutagenesis
Insulin
Disease Management
Encapsulation
Pharmaceutical Preparations
Embryonic Development
Plasticity
Toxicity
Dynamical systems
Embryonic Structures
Safety
Therapeutics

Cite this

Adams, Gary G. ; Buttery, Lee ; Stolnik, Snow ; Morris, Gordon ; Harding, Stephen ; Wang, Nan. / Stem cells : The therapeutic role in the treatment of diabetes mellitus. In: Biotechnology and Genetic Engineering Reviews. 2010 ; Vol. 27, No. 1. pp. 285-304.
@article{154eb264f5284bd090eb9ffcb853d24e,
title = "Stem cells: The therapeutic role in the treatment of diabetes mellitus",
abstract = "The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus. These findings substantiate our method of encapsulation as opposed to the traditional formation strategies, for example those described by Cameron et al, where embryoid body formation is required (Hu 2003; Cameron 2006). These systems are probably used because they are known to generate three germ layers characteristic of embryo development, but EB formation is not an essential requirement in the production of insulin.",
author = "Adams, {Gary G.} and Lee Buttery and Snow Stolnik and Gordon Morris and Stephen Harding and Nan Wang",
year = "2010",
doi = "10.1080/02648725.2010.10648154",
language = "English",
volume = "27",
pages = "285--304",
journal = "Biotechnology and Genetic Engineering Reviews",
issn = "0264-8725",
publisher = "Nottingham University Press",
number = "1",

}

Stem cells : The therapeutic role in the treatment of diabetes mellitus. / Adams, Gary G.; Buttery, Lee; Stolnik, Snow; Morris, Gordon; Harding, Stephen; Wang, Nan.

In: Biotechnology and Genetic Engineering Reviews, Vol. 27, No. 1, 2010, p. 285-304.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stem cells

T2 - Biotechnology and Genetic Engineering Reviews

AU - Adams, Gary G.

AU - Buttery, Lee

AU - Stolnik, Snow

AU - Morris, Gordon

AU - Harding, Stephen

AU - Wang, Nan

PY - 2010

Y1 - 2010

N2 - The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus. These findings substantiate our method of encapsulation as opposed to the traditional formation strategies, for example those described by Cameron et al, where embryoid body formation is required (Hu 2003; Cameron 2006). These systems are probably used because they are known to generate three germ layers characteristic of embryo development, but EB formation is not an essential requirement in the production of insulin.

AB - The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus. These findings substantiate our method of encapsulation as opposed to the traditional formation strategies, for example those described by Cameron et al, where embryoid body formation is required (Hu 2003; Cameron 2006). These systems are probably used because they are known to generate three germ layers characteristic of embryo development, but EB formation is not an essential requirement in the production of insulin.

UR - http://www.scopus.com/inward/record.url?scp=79551578647&partnerID=8YFLogxK

UR - http://www.tandfonline.com/toc/tbgr20/current

U2 - 10.1080/02648725.2010.10648154

DO - 10.1080/02648725.2010.10648154

M3 - Article

VL - 27

SP - 285

EP - 304

JO - Biotechnology and Genetic Engineering Reviews

JF - Biotechnology and Genetic Engineering Reviews

SN - 0264-8725

IS - 1

ER -